Stephanie Mehanna
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Explore the profile of Stephanie Mehanna including associated specialties, affiliations and a list of published articles.
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11
Citations
46
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Recent Articles
1.
Slika A, Haydar C, Chacra J, Al Alam S, Mehanna S, Lteif A, et al.
Curr Res Pharmacol Drug Discov
. 2024 Nov;
7:100205.
PMID: 39554887
The present study investigates the chemotherapeutic potential of two platinum (IV) complexes, P-PENT and P-HEX, against skin cancer . Both complexes exhibited potent cytotoxicity against HaCaT-II-4 cells with IC values...
2.
Mansour N, Mehanna S, Bodman-Smith K, Daher C, Khnayzer R
Pharmaceuticals (Basel)
. 2024 Jan;
17(1).
PMID: 38256884
[Ru(bipy)(dpphen)]Cl (where bipy = 2,2'-bipyridine and dpphen = 2,9-diphenyl-1,10-phenanthroline) (complex ) is a sterically strained compound that exhibits promising in vitro photocytotoxicity on an array of cell lines. Since lung...
3.
Baz J, Khoury A, Elias M, Mansour N, Mehanna S, Hammoud O, et al.
Chem Biol Interact
. 2023 Dec;
388:110834.
PMID: 38103879
The present study investigates the anti-neoplastic activity of a platinum (II) complex, Pt(II)5ClSS, and its platinum (IV) di-hydroxido analogue, Pt(IV)5ClSS, against mesenchymal cells (MCs), lung (A549), melanoma (A375) and breast...
4.
Khoury A, Elias E, Mehanna S, Shebaby W, Deo K, Mansour N, et al.
J Med Chem
. 2022 Dec;
65(24):16481-16493.
PMID: 36480933
A novel platinum(II) complex and its platinum(IV) derivative were synthesized and characterized. Cytotoxicity studies against mesenchymal cells (MCs) and lung (A549), breast (MDA-MB-231), and melanoma (A375) cancer cells demonstrated 7-20-fold...
5.
Saab Y, Oueis E, Mehanna S, Nakad Z, Stephan R, Khnayzer R
Toxics
. 2022 Jul;
10(7).
PMID: 35878262
Phthalate esters (PAEs) are plasticizers associated with multiple toxicities; however, no strict regulations have been implemented to restrict their use in medical applications in Lebanon. Our study aimed at assessing...
6.
Acute cytotoxicity, genotoxicity, and apoptosis induced by petroleum VOC emissions in A549 cell line
Sayyed K, Nour-Eldine W, Rufka A, Mehanna S, Khnayzer R, Abi-Gerges A, et al.
Toxicol In Vitro
. 2022 Jun;
83:105409.
PMID: 35675845
Gasoline is an essential petroleum-derived product powering the automotive economy worldwide. This research focused on the Volatile Organic Component (VOC) cocktail resulting from gasoline evaporation. Petroleum fugitive VOC inhalation by...
7.
Mehanna S, Mansour N, Audi H, Bodman-Smith K, Mroueh M, Taleb R, et al.
RSC Adv
. 2022 May;
9(30):17254-17265.
PMID: 35519840
The use of ruthenium complexes as chemotherapeutic agents has been recently explored as one of the alternatives to conventional treatments. In the present study, two Ru(ii) polypyridyl complexes were synthesized...
8.
Nour-Eldine W, Sayyed K, Harhous Z, Dagher-Hamalian C, Mehanna S, Achkouti D, et al.
J Appl Toxicol
. 2022 Jan;
42(7):1178-1191.
PMID: 35001415
Gasoline exposure has been widely reported in the literature as being toxic to human health. However, the exact underlying molecular mechanisms triggered by its inhalation have not been thoroughly investigated....
9.
Mehanna S, Mansour N, Daher C, Elias M, Dagher C, Khnayzer R
J Photochem Photobiol B
. 2021 Oct;
224:112324.
PMID: 34619435
Visible light has long been recognized as a treatment for many diseases and an essential component of photo-induced chemotherapy. While previous data proved its inherent cytotoxicity, this study is the...
10.
Elias M, Mehanna S, Elias E, Khnayzer R, Daher C
Chem Biol Interact
. 2021 Sep;
348:109644.
PMID: 34508709
Photoactivated chemotherapy (PACT) is an emerging strategy for targeted cancer therapy. Strained Ru complexes with pseudo-octahedral geometry may undergo photo-induced ligand dissociation, forming aquated photoproducts that are significantly more cytotoxic...