Sten Linnarsson
Overview
Explore the profile of Sten Linnarsson including associated specialties, affiliations and a list of published articles.
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103
Citations
18029
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Recent Articles
1.
Adameyko I, Bakken T, Bhaduri A, Chhatbar C, Filbin M, Gate D, et al.
Nat Neurosci
. 2024 Dec;
27(12):2278-2291.
PMID: 39627588
Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single-cell omics data to generate hypotheses...
2.
Amit I, Ardlie K, Arzuaga F, Awandare G, Bader G, Bernier A, et al.
Nat Commun
. 2024 Nov;
15(1):10019.
PMID: 39567491
The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human...
3.
Sariyar S, Sountoulidis A, Hansen J, Marco Salas S, Mardamshina M, Martinez Casals A, et al.
Nat Commun
. 2024 Oct;
15(1):9381.
PMID: 39477961
The respiratory system, including the lungs, is essential for terrestrial life. While recent research has advanced our understanding of lung development, much still relies on animal models and transcriptome analyses....
4.
Liu I, Cruzeiro G, Bjerke L, Rogers R, Grabovska Y, Beck A, et al.
Cancer Cell
. 2024 Sep;
PMID: 39232581
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a...
5.
Carrelha J, Mazzi S, Winroth A, Hagemann-Jensen M, Ziegenhain C, Hogstrand K, et al.
Nat Immunol
. 2024 May;
25(6):1007-1019.
PMID: 38816617
Rare multipotent stem cells replenish millions of blood cells per second through a time-consuming process, passing through multiple stages of increasingly lineage-restricted progenitors. Although insults to the blood-forming system highlight...
6.
Mannens C, Hu L, Lonnerberg P, Schipper M, Reagor C, Li X, et al.
Nature
. 2024 May;
PMID: 38693260
The human brain develops through a tightly organized cascade of patterning events, induced by transcription factor expression and changes in chromatin accessibility. Although gene expression across the developing brain has...
7.
Tian W, Zhou J, Bartlett A, Zeng Q, Liu H, Castanon R, et al.
Science
. 2023 Oct;
382(6667):eadf5357.
PMID: 37824674
Delineating the gene-regulatory programs underlying complex cell types is fundamental for understanding brain function in health and disease. Here, we comprehensively examined human brain cell epigenomes by probing DNA methylation...
8.
Siletti K, Hodge R, Mossi Albiach A, Lee K, Ding S, Hu L, et al.
Science
. 2023 Oct;
382(6667):eadd7046.
PMID: 37824663
The human brain directs complex behaviors, ranging from fine motor skills to abstract intelligence, but the diversity of cell types that support these skills has not been fully described. In...
9.
Jorstad N, Close J, Johansen N, Yanny A, Barkan E, Travaglini K, et al.
Science
. 2023 Oct;
382(6667):eadf6812.
PMID: 37824655
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We used single cell transcriptomics and performed cellular characterization of the human cortex to better understand cortical...
10.
Braun E, Danan-Gotthold M, Borm L, Lee K, Vinsland E, Lonnerberg P, et al.
Science
. 2023 Oct;
382(6667):eadf1226.
PMID: 37824650
The adult human brain comprises more than a thousand distinct neuronal and glial cell types, a diversity that emerges during early brain development. To reveal the precise sequence of events...