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Stefano Cairo

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Articles 77
Citations 2236
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Recent Articles
11.
Brown A, Pan Q, Fan L, Indersie E, Tian C, Timchenko N, et al.
Commun Biol . 2023 Mar; 6(1):249. PMID: 36882565
Prognosis of children with high-risk hepatoblastoma (HB), the most common pediatric liver cancer, remains poor. In this study, we found ribonucleotide reductase (RNR) subunit M2 (RRM2) was one of the...
12.
Muench M, Fomin M, Gutierrez A, Lopez-Terrada D, Gilfanova R, Nosworthy C, et al.
Front Oncol . 2023 Feb; 13:927852. PMID: 36845728
Background & Aims: Hepatocytic cells found during prenatal development have unique features compared to their adult counterparts, and are believed to be the precursors of pediatric hepatoblastoma. The cell-surface phenotype...
13.
Abril-Fornaguera J, Torrens L, Andreu-Oller C, Carrillo-Reixach J, Rialdi A, Balaseviciute U, et al.
Mol Cancer Ther . 2023 Feb; 22(4):485-498. PMID: 36780225
Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB...
14.
Eloranta K, Pihlajoki M, Liljestrom E, Nousiainen R, Soini T, Lohi J, et al.
Front Oncol . 2023 Feb; 13:1118268. PMID: 36776327
Background: In response to hypoxia, tumor cells undergo transcriptional reprogramming including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid-base balance. CAIX overexpression has been shown to correlate...
15.
Brown A, Pan Q, Fan L, Indersie E, Tian C, Timchenko N, et al.
bioRxiv . 2023 Feb; PMID: 36747774
Prognosis of children with high-risk hepatoblastoma (HB), the most common pediatric liver cancer, remains poor. In this study, we found ribonucleotide reductase (RNR) subunit M2 ( ) was one of...
16.
Li Q, Demir S, Del Rio-Alvarez A, Maxwell R, Wagner A, Carrillo-Reixach J, et al.
Cancers (Basel) . 2022 Sep; 14(17). PMID: 36077733
Resistance to conventional chemotherapy remains a huge challenge in the clinical management of hepatoblastoma, the most common liver tumor in childhood. By integrating the gene expression data of hepatoblastoma patients...
17.
Grassilli S, Brugnoli F, Cairo S, Bianchi N, Judde J, Bertagnolo V
J Pers Med . 2022 Jun; 12(6). PMID: 35743776
Triple negative breast cancer (TNBC) represents the most aggressive breast tumor, showing a high intrinsic variability in terms of both histopathological features and response to therapies. Blocking the Akt signaling...
18.
Tayoun T, Faugeroux V, Oulhen M, Deas O, Michels J, Brulle-Soumare L, et al.
JCI Insight . 2022 May; 7(11). PMID: 35511434
DNA damage and genomic instability contribute to non-small cell lung cancer (NSCLC) etiology and progression. However, their therapeutic exploitation is disappointing. CTC-derived explants (CDX) offer systems for mechanistic investigation of...
19.
Pellegrino B, Herencia-Ropero A, Llop-Guevara A, Pedretti F, Moles-Fernandez A, Viaplana C, et al.
Cancer Res . 2022 Apr; 82(8):1646-1657. PMID: 35425960
Significance: This work demonstrates the high accuracy of a histopathology-based test based on the detection of RAD51 nuclear foci in predicting response to PARPi and cisplatin.
20.
Denis de Senneville B, Khoubai F, Bevilacqua M, Labedade A, Flosseau K, Chardot C, et al.
Commun Biol . 2021 Dec; 4(1):1390. PMID: 34903822
Despite recent progress in the characterization of tumour components, the tri-dimensional (3D) organization of this pathological tissue and the parameters determining its internal architecture remain elusive. Here, we analysed the...