Stefanie Muhlhausen
Overview
Explore the profile of Stefanie Muhlhausen including associated specialties, affiliations and a list of published articles.
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19
Citations
345
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Recent Articles
1.
Muhlhausen S, Hurst L
Bioinformatics
. 2022 Mar;
38(9):2626-2627.
PMID: 35244144
Summary: Transgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can...
2.
Muhlhausen S, Schmitt H, Plessmann U, Mienkus P, Sternisek P, Perl T, et al.
BMC Biol
. 2021 Dec;
19(1):258.
PMID: 34863173
Background: Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans, Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons...
3.
Rice A, Morales A, Ho A, Mordstein C, Muhlhausen S, Watson S, et al.
Mol Biol Evol
. 2021 Sep;
38(11):5210.
PMID: 34520550
No abstract available.
4.
Morales A, Rice A, Ho A, Mordstein C, Muhlhausen S, Watson S, et al.
Genome Biol Evol
. 2021 Aug;
13(10).
PMID: 34427640
Owing to a lag between a deleterious mutation's appearance and its selective removal, gold-standard methods for mutation rate estimation assume no meaningful loss of mutations between parents and offspring. Indeed,...
5.
Rice A, Morales A, Ho A, Mordstein C, Muhlhausen S, Watson S, et al.
Mol Biol Evol
. 2020 Jul;
38(1):67-83.
PMID: 32687176
Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization...
6.
Hatje K, Muhlhausen S, Simm D, Kollmar M
Bioessays
. 2019 Sep;
41(11):e1900066.
PMID: 31544971
The major transcript variants of human protein-coding genes are annotated to a certain degree of accuracy combining manual curation, transcript data, and proteomics evidence. However, there is considerable disagreement on...
7.
Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica
Muhlhausen S, Schmitt H, Pan K, Plessmann U, Urlaub H, Hurst L, et al.
Curr Biol
. 2018 Jun;
28(13):2046-2057.e5.
PMID: 29910077
Although the "universal" genetic code is now known not to be universal, and stop codons can have multiple meanings, one regularity remains, namely that for a given sense codon there...
8.
Kollmar M, Muhlhausen S
BMC Evol Biol
. 2017 Sep;
17(1):211.
PMID: 28870165
Background: The last eukaryotic common ancestor already had an amazingly complex cell possessing genomic and cellular features such as spliceosomal introns, mitochondria, cilia-dependent motility, and a cytoskeleton together with several...
9.
Kollmar M, Muhlhausen S
Bioessays
. 2017 Mar;
39(5).
PMID: 28318058
The canonical genetic code ubiquitously translates nucleotide into peptide sequence with several alterations known in viruses, bacteria, mitochondria, plastids, and single-celled eukaryotes. A new hypothesis to explain genetic code changes,...
10.
Kollmar M, Muhlhausen S
RNA Biol
. 2017 Jan;
14(3):293-299.
PMID: 28095181
mRNA decoding by tRNAs and tRNA charging by aminoacyl-tRNA synthetases are biochemically separated processes that nevertheless in general involve the same nucleotides. The combination of charging and decoding determines the...