Stefanie Kerkhofs
Overview
Explore the profile of Stefanie Kerkhofs including associated specialties, affiliations and a list of published articles.
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7
Citations
227
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0
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Recent Articles
1.
Bhardwaj A, Sohni A, Lou C, De Gendt K, Zhang F, Kim E, et al.
Endocrinology
. 2021 Dec;
163(1).
PMID: 34902009
Concordant transcriptional regulation can generate multiple gene products that collaborate to achieve a common goal. Here we report a case of concordant transcriptional regulation that instead drives a single protein...
2.
Sahu B, Pihlajamaa P, Dubois V, Kerkhofs S, Claessens F, Janne O
Nucleic Acids Res
. 2014 Jan;
42(7):4230-40.
PMID: 24459135
The DNA-binding domains (DBDs) of class I steroid receptors-androgen, glucocorticoid, progesterone and mineralocorticoid receptors-recognize a similar cis-element, an inverted repeat of 5'-AGAACA-3' with a 3-nt spacer. However, these receptors regulate...
3.
Kerkhofs S, Dubois V, De Gendt K, Helsen C, Clinckemalie L, Spans L, et al.
FASEB J
. 2012 Jul;
26(10):4360-72.
PMID: 22798427
The androgen receptor (AR) recognizes two types of DNA elements that are dimers of 5'-AGAACA-3'-like hexamers, either organized as inverted or direct repeats. We developed a mouse model [(specificity affecting...
4.
Bhardwaj A, Song H, Beildeck M, Kerkhofs S, Castoro R, Shanker S, et al.
Mol Endocrinol
. 2012 Feb;
26(4):538-49.
PMID: 22322598
Mammalian male fertility depends on the epididymis, a highly segmented organ that promotes sperm maturation and protects sperm from oxidative damage. Remarkably little is known about how gene expression is...
5.
Helsen C, Kerkhofs S, Clinckemalie L, Spans L, Laurent M, Boonen S, et al.
Mol Cell Endocrinol
. 2011 Aug;
348(2):411-7.
PMID: 21801809
The gene family of nuclear receptors is characterized by the presence of a typical, well conserved DNA-binding domain. In general, two zinc coordinating modules are folded such that an α-helix...
6.
Tanner T, Denayer S, Geverts B, Van Tilborgh N, Kerkhofs S, Helsen C, et al.
Cell Mol Life Sci
. 2010 Feb;
67(11):1919-27.
PMID: 20186458
The androgen receptor protein has specific domains involved in DNA binding, ligand binding, and transactivation, whose activities need to be integrated during transcription activation. The hinge region, more particular a...
7.
Claessens F, Denayer S, Van Tilborgh N, Kerkhofs S, Helsen C, Haelens A
Nucl Recept Signal
. 2008 Jul;
6:e008.
PMID: 18612376
Androgens control male sexual development and maintenance of the adult male phenotype. They have very divergent effects on their target organs like the reproductive organs, muscle, bone, brain and skin....