Stefan Nierkens
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Explore the profile of Stefan Nierkens including associated specialties, affiliations and a list of published articles.
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Articles
181
Citations
3288
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Recent Articles
11.
Boer J, Ilan U, Boeree A, Langenberg K, Koster J, Koudijs M, et al.
Hemasphere
. 2024 Jul;
8(7):e122.
PMID: 39011126
Over the past 10 years, institutional and national molecular tumor boards have been implemented for relapsed or refractory pediatric cancer to prioritize targeted drugs for individualized treatment based on actionable...
12.
Beerepoot S, Verbeke J, Plantinga M, Nierkens S, Pouwels P, Wolf N, et al.
Am J Med Genet A
. 2024 Jun;
194(11):e63800.
PMID: 38934054
We report three siblings homozygous for CSF1R variant c.1969 + 115_1969 + 116del to expand the phenotype of "brain abnormalities, neurodegeneration, and dysosteosclerosis" (BANDDOS) and discuss its link with "adult...
13.
Jansen S, Cutilli A, de Koning C, van Hoesel M, Frederiks C, Saiz Sierra L, et al.
iScience
. 2024 Jun;
27(6):110072.
PMID: 38883813
The intestine is vulnerable to chemotherapy-induced damage due to the high rate of intestinal epithelial cell (IEC) proliferation. We have developed a human intestinal organoid-based 3D model system to study...
14.
Beerepoot S, Boelens J, Lindemans C, de Witte M, Nierkens S, Vrancken A, et al.
J Neurol
. 2024 Apr;
271(7):4028-4038.
PMID: 38564053
Metachromatic leukodystrophy (MLD) is a neuro-metabolic disorder due to arylsulfatase A deficiency, causing demyelination of the central and peripheral nervous system. Hematopoietic cell transplantation (HCT) can provide a symptomatic and...
15.
Forbes C, Nierkens S, Cornel A
Immunotargets Ther
. 2024 Apr;
13:183-194.
PMID: 38558927
Natural killer (NK)-cells are innate immune cells with potent anti-tumor capacity, capable of recognizing target cells without prior exposure. For this reason, NK-cells are recognized as a useful source of...
16.
Cornel A, van der Sman L, van Dinter J, Arrabito M, Dunnebach E, van Hoesel M, et al.
J Immunother Cancer
. 2024 Mar;
12(3).
PMID: 38519054
Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds. A subpopulation of atypical, major histocompatibility complex-I...
17.
Alieva M, Barrera Roman M, de Blank S, Petcu D, Zeeman A, Dautzenberg N, et al.
Nat Protoc
. 2024 Mar;
19(7):2052-2084.
PMID: 38504137
Modeling immuno-oncology by using patient-derived material and immune cell co-cultures can advance our understanding of immune cell tumor targeting in a patient-specific manner, offering leads to improve cellular immunotherapy. However,...
18.
Admiraal R, Versluijs A, Huitema A, Ebskamp L, Lacna A, de Kanter C, et al.
Cytotherapy
. 2024 Mar;
26(6):599-605.
PMID: 38466262
Background: Graft-versus-host disease (GvHD) and rejection are main limitations of cord blood transplantation (CBT), more so in patients with severe inflammation or previous rejections. While rigorous T-cell depletion with antithymocyte...
19.
Smeets M, Steeghs E, Orsel J, Stalpers F, Vermeeren M, Veltman C, et al.
Haematologica
. 2024 Mar;
109(7):2073-2084.
PMID: 38426282
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can hijack the normal bone marrow microenvironment to create a leukemic niche which facilitates blast cell survival and promotes drug resistance. Bone marrow-derived mesenchymal...
20.
Maier C, Klose C, Seitz C, Heubach F, Doring M, Meisel R, et al.
Blood Adv
. 2024 Jan;
8(9):2160-2171.
PMID: 38290133
Anti-T lymphocyte globulin (ATLG) significantly reduces the risk of engraftment failure in allogeneic hematopoietic stem cell transplant (HSCT) but hampers posttransplant immune reconstitution. We hypothesized that in patients receiving haploidentical...