Stefan Koster
Overview
Explore the profile of Stefan Koster including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
824
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0
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Recent Articles
1.
Chandra P, He L, Zimmerman M, Yang G, Koster S, Ouimet M, et al.
mBio
. 2020 Jul;
11(4).
PMID: 32636249
Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. How these metabolic shifts influence the outcome of infection by intracellular pathogens remains incompletely understood. (Mtb) modulates host metabolic pathways...
2.
Mittal E, Skowyra M, Uwase G, Tinaztepe E, Mehra A, Koster S, et al.
mBio
. 2018 Nov;
9(6).
PMID: 30482832
Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in...
3.
Koster S, Klevorn T, Papavinasasundaram K, Sassetti C, Portal-Celhay C, Philips J
Vaccine
. 2018 Jan;
36(7):939-944.
PMID: 29343411
Development of a new vaccine against tuberculosis is urgently needed. Recent work has demonstrated that two related LC3-associated trafficking pathways, autophagy and LC3-associated phagocytosis (LAP), enhance antigen presentation and might...
4.
Koster S, Upadhyay S, Philips J
Autophagy
. 2018 Jan;
14(3):552-554.
PMID: 29313424
M. tuberculosis causes an enormous worldwide burden of disease. Its success depends upon subverting the antimicrobial capacity of macrophages. We have known for decades that M. tuberculosis impairs phagosomal trafficking...
5.
Koster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, et al.
Proc Natl Acad Sci U S A
. 2017 Oct;
114(41):E8711-E8720.
PMID: 28973896
' success as a pathogen comes from its ability to evade degradation by macrophages. Normally macrophages clear microorganisms that activate pathogen-recognition receptors (PRRs) through a lysosomal-trafficking pathway called "LC3-associated phagocytosis"...
6.
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
Ouimet M, Koster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, et al.
Nat Immunol
. 2016 Apr;
17(6):677-86.
PMID: 27089382
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. We found that...
7.
Sakowski E, Koster S, Portal Celhay C, Park H, Shrestha E, Hetzenecker S, et al.
PLoS Pathog
. 2015 Jul;
11(7):e1005076.
PMID: 26225865
The success of Mycobacterium tuberculosis (Mtb) as a pathogen rests upon its ability to grow intracellularly in macrophages. Interferon-gamma (IFN-γ) is critical in host defense against Mtb and stimulates macrophage...
8.
Koster S, van Pee K, Yildiz O
Methods Enzymol
. 2015 May;
557:149-66.
PMID: 25950964
OmpG is a pore-forming protein from E. coli outer membranes. Unlike the classical outer membrane porins, which are trimers, the OmpG channel is a monomeric β-barrel made of 14 antiparallel...
9.
Aktas M, Koster S, Kizilirmak S, Casanova J, Betz H, Fritz C, et al.
FEBS J
. 2014 Jun;
281(15):3523-41.
PMID: 24931117
Structured Digital Abstract: Pcs and Pcs bind by molecular sieving (1, 2, 3).
10.
Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation
Koster S, van Pee K, Hudel M, Leustik M, Rhinow D, Kuhlbrandt W, et al.
Nat Commun
. 2014 Apr;
5:3690.
PMID: 24751541
Listeriolysin O (LLO) is an essential virulence factor of Listeria monocytogenes that causes listeriosis. Listeria monocytogenes owes its ability to live within cells to the pH- and temperature-dependent pore-forming activity...