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Stefan Hettwer

Explore the profile of Stefan Hettwer including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 699
Followers 0
Related Specialties
General Medicine
Biochemistry
Cardiology & Vascular Diseases
Top 10 Co-Authors
Dominik Steubl
Marcel Roos
Uwe Heemann
Lutz Renders
Pius Dahinden
Peter Luppa
Karl Werdan
Carsten A Wagner
Sally Spendiff
Christoph Schmaderer
Published In
Clin Res Cardiol
PLoS One
Clin Chem Lab Med
FASEB J
Skelet Muscle
Affiliations
Soon will be listed here.
Recent Articles
1.
Modulation of the Acetylcholine Receptor Clustering Pathway Improves Neuromuscular Junction Structure and Muscle Strength in a Mouse Model of Congenital Myasthenic Syndrome
Spendiff S, Howarth R, McMacken G, Davey T, Quinlan K, OConnor E, et al.
Front Mol Neurosci . 2021 Jan; 13:594220. PMID: 33390901
Congenital myasthenic syndromes (CMS) are a diverse group of inherited neuromuscular disorders characterized by a failure of synaptic transmission at the neuromuscular junction (NMJ). CMS often present early with fatigable...
2.
Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish
OConnor E, Cairns G, Spendiff S, Burns D, Hettwer S, Mader A, et al.
Cells . 2019 Aug; 8(8). PMID: 31394789
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by impaired function of the neuromuscular junction (NMJ). This is due to defects in one of the many...
3.
Plasma C-terminal agrin fragment and rapid kidney function decline in chronic kidney disease patients
Lorenz G, Hettwer S, McCallum W, Angermann S, Wen M, Schmaderer C, et al.
Medicine (Baltimore) . 2019 May; 98(19):e15597. PMID: 31083248
C-terminal agrin fragment (tCAF) is a promising biomarker for glomerular filtration. Data regarding biomarkers that have the ability to predict rapid progression of chronic kidney disease (CKD) are sparse but...
4.
MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion
OConnor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, et al.
Hum Mol Genet . 2018 Feb; 27(8):1434-1446. PMID: 29462312
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterized by compromised function of the neuromuscular junction, manifesting with fatigable muscle weakness. Mutations in MYO9A were previously identified...
5.
Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy
Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg M, et al.
Front Cell Neurosci . 2018 Feb; 12:17. PMID: 29440993
Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, to death....
6.
Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians
Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais J, et al.
J Physiol . 2016 Sep; 594(24):7361-7379. PMID: 27619626
Key Points: Mitochondria are frequently implicated in the ageing of skeletal muscle, although the role of denervation in modulating mitochondrial function in ageing muscle is unknown. We show that increased...
7.
Failed reinnervation in aging skeletal muscle
Aare S, Spendiff S, Vuda M, Elkrief D, Perez A, Wu Q, et al.
Skelet Muscle . 2016 Sep; 6(1):29. PMID: 27588166
Background: Skeletal muscle displays a marked accumulation of denervated myofibers at advanced age, which coincides with an acceleration of muscle atrophy. Methods: In this study, we evaluated the hypothesis that...
8.
The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule
Daryadel A, Haubitz M, Figueiredo M, Steubl D, Roos M, Mader A, et al.
PLoS One . 2016 Jul; 11(7):e0157905. PMID: 27380275
Agrin, a multidomain proteoglycan and neurotrypsin, a neuronal serine protease, are important for forming (neuromuscular) synapses. Proteolytical activity of neurotrypsin produces a C-terminal fragment of agrin, termed CAF, of approximately...
9.
Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation
Scherbakov N, Knops M, Ebner N, Valentova M, Sandek A, Grittner U, et al.
J Cachexia Sarcopenia Muscle . 2016 Apr; 7(1):60-7. PMID: 27066319
Background: C-terminal Agrin Fragment (CAF) has been proposed as a novel biomarker for sarcopenia originating from the degeneration of the neuromuscular junctions. In patients with stroke muscle wasting is a...
10.
Comparison of Peritoneal Low-Molecular-Weight-Protein-Removal in CCPD and CAPD Patients Based on C-Terminal Agrin Fragment Clearance
Steubl D, Roos M, Hettwer S, Angermann S, Wen M, Schmaderer C, et al.
Kidney Blood Press Res . 2016 Mar; 41(2):175-85. PMID: 26959245
Background/aims: This study compares the peritoneal elimination of the low-molecular-weight-protein (LMWP) C-terminal agrin fragment (tCAF, size 22 kDa), a promising biomarker for kidney function, in continuous cycling peritoneal dialysis (CCPD)...