Stefan G Kauschke
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Explore the profile of Stefan G Kauschke including associated specialties, affiliations and a list of published articles.
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12
Citations
91
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Recent Articles
1.
Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, et al.
Cell
. 2024 Oct;
187(25):7314-7334.e21.
PMID: 39368477
Cellular senescence plays critical roles in aging, regeneration, and disease; yet, the ability to discern its contributions across various cell types to these biological processes remains limited. In this study,...
2.
Hofer B, Simbrunner B, Konigshofer P, Brusilovskaya K, Petrenko O, Taru V, et al.
Dig Liver Dis
. 2024 Sep;
57(2):450-458.
PMID: 39343656
Background: Cirrhosis is associated with a proinflammatory environment. Aims: To analyse aetiology-specific inflammation patterns in compensated cirrhosis in animal models and patients. Methods: Portal pressure (PP), fibrosis (collagen proportionate area...
3.
Petrenko O, Konigshofer P, Brusilovskaya K, Hofer B, Bareiner K, Simbrunner B, et al.
iScience
. 2024 Mar;
27(3):109301.
PMID: 38469563
Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression...
4.
Wang X, Wu X, Wu H, Xiao H, Hao S, Wang B, et al.
Sci Adv
. 2023 Nov;
9(44):eadh2884.
PMID: 37910621
Overeating disorders largely contribute to worldwide incidences of obesity. Available treatments are limited. Here, we discovered that long-term chemogenetic activation of ventrolateral periaqueductal gray (vlPAG) GABAergic cells rescue obesity of...
5.
Markert E, Klein H, Viollet C, Rust W, Strobel B, Kauschke S, et al.
Front Cell Dev Biol
. 2022 Sep;
10:910040.
PMID: 36092714
The therapeutic potential of pluripotent stem cells is great as they promise to usher in a new era of medicine where cells or organs may be prescribed to replace dysfunctional...
6.
Achberger K, Cipriano M, Duchs M, Schon C, Michelfelder S, Stierstorfer B, et al.
Stem Cell Reports
. 2021 Sep;
16(9):2242-2256.
PMID: 34525384
Gene therapies using adeno-associated viruses (AAVs) are among the most promising strategies to treat or even cure hereditary and acquired retinal diseases. However, the development of new efficient AAV vectors...
7.
Lewis N, Patnaude L, Pelletier J, Souza D, Lukas S, King F, et al.
PLoS One
. 2014 Jun;
9(6):e100883.
PMID: 24967665
GPBAR1 is a G protein-coupled receptor that is activated by certain bile acids and plays an important role in the regulation of bile acid synthesis, lipid metabolism, and energy homeostasis....
8.
Pautsch A, Stadler N, Lohle A, Rist W, Berg A, Glocker L, et al.
Biochemistry
. 2013 Apr;
52(20):3523-31.
PMID: 23621087
Glucokinase (GK) plays a major role in the regulation of blood glucose homeostasis in both the liver and the pancreas. In the liver, GK is controlled by the GK regulatory...
9.
Wolff M, Kauschke S, Schmidt S, Heilker R
J Biomol Screen
. 2008 Sep;
13(9):837-46.
PMID: 18812575
In the liver, glucokinase (GK) regulatory protein (GKRP) negatively modulates the metabolic enzyme GK by locking it in an inactive state in the nucleus. Here, the authors established a high...
10.
Zibrova D, Grempler R, Streicher R, Kauschke S
Biochem J
. 2008 Feb;
412(2):359-66.
PMID: 18298402
In Type 2 diabetes, increased glycogenolysis contributes to the hyperglycaemic state, therefore the inhibition of GP (glycogen phosphorylase), a key glycogenolytic enzyme, is one of the possibilities to lower plasma...