Stefan Barghorn
Overview
Explore the profile of Stefan Barghorn including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1089
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0
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Recent Articles
1.
Ashton N, Keshavan A, Brum W, Andreasson U, Arslan B, Droescher M, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14508.
PMID: 39907496
Introduction: The Alzheimer's Association Global Biomarker Standardization Consortium conducted a blinded case-control study to learn which phosphorylated tau (p-tau) assays provide the largest fold-changes in Alzheimer's disease (AD) versus non-AD...
2.
Ashton N, Keshavan A, Brum W, Andreasson U, Arslan B, Droescher M, et al.
medRxiv
. 2024 Sep;
PMID: 39228740
Background: Phosphorylated tau (p-tau) is a specific blood biomarker for Alzheimer's disease (AD) pathology. Multiple p-tau biomarkers on several analytical platforms are poised for clinical use. The Alzheimer's Association Global...
3.
Frey B, Holzinger D, Taylor K, Ehrnhoefer D, Striebinger A, Biesinger S, et al.
Acta Neuropathol Commun
. 2024 Jul;
12(1):115.
PMID: 39004770
No abstract available.
4.
Frey B, Holzinger D, Taylor K, Ehrnhoefer D, Striebinger A, Biesinger S, et al.
Acta Neuropathol Commun
. 2023 Nov;
11(1):181.
PMID: 37964332
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in Alzheimer's disease (AD). However, the...
5.
Jacobson P, Mothe A, Levy A, Krakovsky M, Hooker B, Zhang X, et al.
Transl Stroke Res
. 2023 Jun;
15(4):805-817.
PMID: 37326791
Repulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain...
6.
Loberg L, Chhaya M, Ibraghimov A, Tarcsa E, Striebinger A, Popp A, et al.
MAbs
. 2021 Feb;
13(1):1887628.
PMID: 33596779
ABT-736 is a humanized monoclonal antibody generated to target a specific conformation of the amyloid-beta (Aβ) protein oligomer. Development of ABT-736 for Alzheimer's disease was discontinued due to severe adverse...
7.
Schlegel K, Awwad K, Heym R, Holzinger D, Doell A, Barghorn S, et al.
Acta Neuropathol Commun
. 2019 Nov;
7(1):177.
PMID: 31722749
Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau...
8.
Demicheva E, Cui Y, Bardwell P, Barghorn S, Kron M, Meyer A, et al.
Cell Rep
. 2015 Mar;
10(11):1887-98.
PMID: 25801027
Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis (MS). In autopsy material...
9.
Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model
Dorostkar M, Burgold S, Filser S, Barghorn S, Schmidt B, Anumala U, et al.
Brain
. 2014 Oct;
137(Pt 12):3319-26.
PMID: 25281869
Cognitive decline in Alzheimer's disease is attributed to loss of functional synapses, most likely caused by synaptotoxic, oligomeric forms of amyloid-β. Many treatment options aim at reducing amyloid-β levels in...
10.
Muller T, Barghorn S, Lutge S, Haas T, Mueller R, Gerlach B, et al.
J Neural Transm (Vienna)
. 2014 Sep;
122(6):841-8.
PMID: 25209051
Repeated intrathecal application of the sustained release steroid triamcinolone acetonide is beneficial in progressive multiple sclerosis patients. Its putative regenerative effect may involve regulation of the repulsive guidance molecule A...