Stanislaw J Czuczwar
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Explore the profile of Stanislaw J Czuczwar including associated specialties, affiliations and a list of published articles.
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288
Citations
4079
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Recent Articles
1.
Albrecht J, Czuczwar S, Zielinska M, Miziak B
Neurochem Res
. 2025 Jan;
50(2):84.
PMID: 39843842
Methionine sulfoximine (MSO) is a compound originally discovered as a byproduct of agene-based milled flour maturation. MSO irreversibly inhibits the astrocytic enzyme glutamine synthase (GS) but also interferes with the...
2.
Pluta R, Kocki J, Bogucki J, Bogucka-Kocka A, Czuczwar S
J Alzheimers Dis
. 2024 Dec;
103(2):627-634.
PMID: 39686609
Background: Changes in the Alzheimer's disease-related apolipoprotein genes expression, occurring parallel with brain ischemia-induced neurodegeneration in the hippocampal CA3 area, may be crucial for the development of memory loss and...
3.
Blaszczyk B, Czuczwar S, Miziak B
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684724
About 40-50% of patients with drug-resistant epilepsy do not properly respond to pharmacological therapy with antiseizure medications (ASMs). Recently approved by the US Food and Drug Administration and European Medicines...
4.
Kamieniak M, Kosmider K, Miziak B, Czuczwar S
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684654
Oxidative stress develops when there is an excess of oxidants leading to molecular and cellular damage. Seizure activity leads to oxidative stress and the resulting increased lipid peroxidation. Generally, antiseizure...
5.
Czapinska-Ciepiela E, Luszczki J, Czapinski P, Czuczwar S, Lason W
Pharmacol Rep
. 2024 May;
76(4):623-643.
PMID: 38776036
Among clinically highly efficient antiseizure medications (ASMs) there are modifiers of the presynaptic release machinery. Of them, levetiracetam and brivaracetam show a high affinity to the synaptic vesicle protein type...
6.
Pluta R, Bogucka-Kocka A, Bogucki J, Kocki J, Czuczwar S
J Alzheimers Dis
. 2024 May;
99(4):1375-1383.
PMID: 38759019
Background: Currently, no evidence exists on the expression of apoptosis (CASP3), autophagy (BECN1), and mitophagy (BNIP3) genes in the CA3 area after ischemia with long-term survival. Objective: The goal of...
7.
Pluta R, Czuczwar S
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542064
Recent evidence indicates that experimental brain ischemia leads to dementia with an Alzheimer's disease-like type phenotype and genotype. Based on the above evidence, it was hypothesized that brain ischemia may...
8.
Czuczwar S, Kocki J, Miziak B, Bogucki J, Bogucka-Kocka A, Pluta R
J Alzheimers Dis
. 2024 Feb;
98(1):151-161.
PMID: 38393914
Background: Understanding the phenomena underlying the non-selective susceptibility to ischemia of pyramidal neurons in the CA3 is important from the point of view of elucidating the mechanisms of memory loss...
9.
Pluta R, Czuczwar S
Int J Mol Sci
. 2024 Jan;
25(2).
PMID: 38279289
The article presents the latest data on pathological changes after cerebral ischemia caused by cardiac arrest. The data include amyloid accumulation, tau protein modification, neurodegenerative and cognitive changes, and gene...
10.
Miziak B, Blaszczyk B, Chroscinska-Krawczyk M, Czuczwar S
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38139396
Experimental studies reveal that caffeine (trimethylxanthine) at subconvulsive doses, distinctly reduced the anticonvulsant activity of numerous antiseizure medications (ASMs) in rodents, oxcarbazepine, tiagabine and lamotrigine being the exceptions. Clinical data...