Srinivasan Shanmugarajan
Overview
Explore the profile of Srinivasan Shanmugarajan including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
168
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Recent Articles
1.
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde L, Ramesh G, et al.
Int J Mol Sci
. 2017 Nov;
18(11).
PMID: 29156538
The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity...
2.
Sundaram K, Sambandam Y, Shanmugarajan S, Rao D, Reddy S
Bone Rep
. 2017 Aug;
7:26-32.
PMID: 28840181
Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP)...
3.
Shanmugarajan S, Haycraft C, Reddy S, Ries W
J Cell Biochem
. 2011 Nov;
113(4):1274-81.
PMID: 22105856
Receptor activator of NF-κB ligand (RANKL)-RANK receptor signaling to induce NFATc1 transcription factor is critical for osteoclast differentiation and bone resorption. RANK adaptor proteins, tumor necrosis factor receptor-associated factors (TRAFs)...
4.
Sundaram K, Shanmugarajan S, Rao D, Reddy S
Endocrinology
. 2011 Sep;
152(11):4180-9.
PMID: 21878516
Paget's disease of the bone (PDB) is an autosomal dominant trait with genetic heterogeneity, characterized by abnormal osteoclastogenesis. Sequestosome 1 (p62) is a scaffold protein that plays an important role...
5.
Sambandam Y, Blanchard J, Daughtridge G, Kolb R, Shanmugarajan S, Pandruvada S, et al.
J Cell Biochem
. 2010 Aug;
111(5):1179-87.
PMID: 20717918
Microgravity (µXg) leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast (OCL) is the multinucleated bone-resorbing cell. In this study, we used the NASA developed...
6.
Shanmugarajan S, Beeson C, Reddy S
Endocrinology
. 2010 Jul;
151(9):4389-99.
PMID: 20610564
Osteoclast inhibitory peptide-1 (OIP) is an autocrine/paracrine inhibitor of osteoclast differentiation, and mice that overexpress OIP-1 in osteoclast lineage cells develop an osteopetrosis bone phenotype. In this study, we show...
7.
Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease
Contreras M, Ries W, Shanmugarajan S, Arboleda G, Singh I, Singh A
Biochim Biophys Acta
. 2010 May;
1802(7-8):601-8.
PMID: 20441793
Krabbe disease is an inherited lysosomal disorder in which galactosylsphingosine (psychosine) accumulates mainly in the central nervous system. To gain insight into the possible mechanism(s) that may be participating in...
8.
Pandruvada S, Yuvaraj S, Liu X, Sundaram K, Shanmugarajan S, Ries W, et al.
Int J Cancer
. 2009 Oct;
126(10):2319-29.
PMID: 19816883
Oral squamous cell carcinomas (OSCC) are malignant tumors with a potent activity of local bone invasion; however, the molecular mechanisms of tumor osteolysis are unclear. In this study, we identified...
9.
Shanmugarajan S, Tsuruga E, Swoboda K, Maria B, Ries W, Reddy S
J Pathol
. 2009 May;
219(1):52-60.
PMID: 19434631
Spinal muscular atrophy (SMA) is characterized by degenerating lower motor neurons and an increased incidence of congenital bone fractures. Survival motor neuron (SMN) levels are significantly reduced due to deletions/mutations...
10.
Shanmugarajan S, Kawanabe N, Koide M, Tsuruga E, Arroyo J, Key Jr L, et al.
J Cell Biochem
. 2009 Mar;
107(1):104-11.
PMID: 19259951
Immune cell products such as interferon (IFN)-gamma and interleukin (IL)-12 are potent inhibitors of osteoclast formation. We previously characterized the human osteoclast inhibitory peptide-1 (OIP-1/hSca), a Ly-6 gene family member...