Srinivas Maddi
Overview
Explore the profile of Srinivas Maddi including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
12
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0
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Recent Articles
1.
Chunduri V, Maddi S
ADMET DMPK
. 2023 Feb;
11(1):1-32.
PMID: 36778905
Drug discovery and development have become a very time-consuming and expensive process. Preclinical animal models have become the gold standard for studying drug pharmacokinetic and toxicity parameters. However, the involvement...
2.
Nair S, Kumar S, Paidi V, Sistla R, Kantheti D, Polimera S, et al.
ACS Med Chem Lett
. 2020 Jul;
11(7):1402-1409.
PMID: 32676146
IRAK4 is an attractive therapeutic target for the treatment of inflammatory conditions. Structure guided optimization of a nicotinamide series of inhibitors has been expanded to explore the IRAK4 front pocket....
3.
Goud T, Maddi S, Nayakanti D, Thatipamula R
Drug Metab Pers Ther
. 2016 May;
31(2):123-30.
PMID: 27166727
Background: Ritonavir is an antiretroviral drug to treat HIV AIDS and inhibits cytochrome P450 3A4. To treat diabetes mellitus in HIV, repaglinide is coadministered with ritonavir in the clinic. Multiple...
4.
Maddi S, Scriba G, Rao Yamsani M
Drug Metabol Drug Interact
. 2011 Jul;
26(2):81-6.
PMID: 21732706
The binding of nateglinide (NA) enantiomers with human plasma (HP), human serum albumin (HSA) and bovine serum albumin (BSA) was investigated. The protein binding was studied over a drug concentration...
5.
Maddi S, Rao Yamsani M, Seeling A, Scriba G
Chirality
. 2009 Jun;
22(2):262-6.
PMID: 19496159
The binding of the (R)- and (S)-enantiomers of amlodipine to bovine serum albumin (BSA), human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), and human plasma (HP) was studied by equilibrium dialysis...
6.
Maddi S, Keshetty S, Mohan Ega C, Yamasani M, Scriba G
J Sep Sci
. 2007 Jul;
30(12):1875-80.
PMID: 17638349
A simple stereoselective high performance liquid chromatographic method was developed for the determination of the in vitro transport of the enantiomers of nateglinide (N-(trans-4-isopropylcyclohexyl-carbonyl)-phenylalanine) in the rat intestine using a...