Srabani Mitra
Overview
Explore the profile of Srabani Mitra including associated specialties, affiliations and a list of published articles.
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22
Citations
554
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Recent Articles
1.
Gavrilin M, McAndrew C, Prather E, Tsai M, Spitzer C, Song M, et al.
Front Immunol
. 2020 Apr;
11:461.
PMID: 32265920
Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation...
2.
Mitra S, Dolvin E, Krishnamurthy K, Wewers M, Sarkar A
PLoS One
. 2019 Jan;
13(12):e0209931.
PMID: 30596757
Although the study of pathogen sensing by host defense systems continues to uncover a role for inflammasome components specific to particular pathogens, gaps remain in our knowledge. After internalization, Francisella...
3.
Mitra S, Sarkar A
Purinergic Signal
. 2018 Dec;
15(1):119-123.
PMID: 30547277
The pro-inflammatory cytokine IL-1β is a secreted protein that is cleaved by caspase-1 during inflammasome activation upon recognition of internal and external insults to cells. Purinergic receptor P2X7 has been...
4.
Mitra S, Exline M, Habyarimana F, Gavrilin M, Baker P, Masters S, et al.
Am J Respir Cell Mol Biol
. 2018 Jan;
59(1):56-64.
PMID: 29365280
Lung endothelial cell apoptosis and injury occur throughout all stages of acute lung injury/acute respiratory distress syndrome and impact disease progression. Caspases 1, 4, and 5 are essential for completion...
5.
Sundaram K, Rahman M, Mitra S, Knoell D, Woodiga S, King S, et al.
PLoS One
. 2016 Sep;
11(9):e0161931.
PMID: 27597997
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription factor IκBζ, are associated with increased susceptibility to invasive...
6.
Mitra S, Wewers M, Sarkar A
PLoS One
. 2015 Dec;
10(12):e0145607.
PMID: 26710067
Lung endothelial cell apoptosis and injury occurs throughout all stages of acute lung injury (ALI/ARDS) and impacts disease progression. Lung endothelial injury has traditionally been focused on the role of...
7.
Shamaa O, Mitra S, Gavrilin M, Wewers M
PLoS One
. 2015 Nov;
10(11):e0142203.
PMID: 26599267
Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell extracts that spontaneously activate caspase-1, it is now clear...
8.
Ghonime M, Mitra S, Eldomany R, Wewers M, Gavrilin M
PLoS One
. 2015 May;
10(5):e0127278.
PMID: 25993107
Inflammasome activation is a two-step process where step one, priming, prepares the inflammasome for its subsequent activation, by step two. Classically step one can be induced by LPS priming followed...
9.
Rahman M, Mitra S, Sarkar A, Wewers M
PLoS One
. 2015 Feb;
10(2):e0117330.
PMID: 25658455
Background: Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also...
10.
Sundaram K, Mitra S, Gavrilin M, Wewers M
Am J Respir Cell Mol Biol
. 2015 Jan;
53(3):400-11.
PMID: 25629767
Asthma is a chronic lung disease characterized by inflammation centered upon bronchial epithelium. House dust mite is one of the most common respiratory allergens that trigger exacerbations of asthma. IκBζ...