Spencer J Sherwin
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Explore the profile of Spencer J Sherwin including associated specialties, affiliations and a list of published articles.
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31
Citations
661
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Recent Articles
1.
Kandangwa P, Cheng K, Patel M, Sherwin S, De Silva R, Weinberg P
Ann Biomed Eng
. 2024 Sep;
53(1):144-157.
PMID: 39287909
Purpose: The patchy anatomical distribution of atherosclerosis has been attributed to variation in haemodynamic wall shear stress (WSS). The consensus is that low WSS and a high Oscillatory Shear Index...
2.
Arshad M, Cheng S, van Reeuwijk M, Sherwin S, Weinberg P
Biotechnol Bioeng
. 2023 Jan;
120(5):1254-1268.
PMID: 36633017
Effects of hemodynamic shear stress on endothelial cells have been extensively investigated using the "swirling well" method, in which cells are cultured in dishes or multiwell plates placed on an...
3.
Kandangwa P, Torii R, Gatehouse P, Sherwin S, Weinberg P
Front Bioeng Biotechnol
. 2022 Aug;
10:962687.
PMID: 36017352
The patchy distribution of atherosclerosis within the arterial system is consistent with a controlling influence of hemodynamic wall shear stress (WSS). Patterns of low, oscillatory and transverse WSS have been...
4.
Reavette R, Sherwin S, Tang M, Weinberg P
Front Bioeng Biotechnol
. 2022 Jan;
9:737055.
PMID: 35004634
Heart failure is treatable, but in the United Kingdom, the 1-, 5- and 10-year mortality rates are 24.1, 54.5 and 75.5%, respectively. The poor prognosis reflects, in part, the lack...
5.
Arshad M, Rowland E, Riemer K, Sherwin S, Weinberg P
Biotechnol Bioeng
. 2021 Oct;
119(1):72-88.
PMID: 34612513
Effects of fluid dynamics on cells are often studied by growing the cells on the base of cylindrical wells or dishes that are swirled on the horizontal platform of an...
6.
Arshad M, Ghim M, Mohamied Y, Sherwin S, Weinberg P
J R Soc Interface
. 2021 Jan;
18(174):20200772.
PMID: 33435845
The alignment of arterial endothelial cells (ECs) with the mean wall shear stress (WSS) vector is the prototypical example of their responsiveness to flow. However, evidence for this behaviour rests...
7.
Mariscal-Harana J, Charlton P, Vennin S, Aramburu J, Florkow M, van Engelen A, et al.
Am J Physiol Heart Circ Physiol
. 2020 Oct;
320(2):H494-H510.
PMID: 33064563
Central blood pressure (cBP) is a highly prognostic cardiovascular (CV) risk factor whose accurate, invasive assessment is costly and carries risks to patients. We developed and assessed novel algorithms for...
8.
Reavette R, Sherwin S, Tang M, Weinberg P
Proc Inst Mech Eng H
. 2020 Jul;
234(11):1260-1276.
PMID: 32650691
Pressure-velocity-based analysis of arterial wave intensity gives clinically relevant information about the performance of the heart and vessels, but its utility is limited because accurate pressure measurements can only be...
9.
Ghim M, Alpresa P, Yang S, Braakman S, Gray S, Sherwin S, et al.
Am J Physiol Heart Circ Physiol
. 2017 Jul;
313(5):H959-H973.
PMID: 28754719
Transport of macromolecules across vascular endothelium and its modification by fluid mechanical forces are important for normal tissue function and in the development of atherosclerosis. However, the routes by which...
10.
Mohamied Y, Sherwin S, Weinberg P
J Biomech
. 2016 Nov;
50:102-109.
PMID: 27863740
The patchy distribution of atherosclerosis within arteries is widely attributed to local variation in haemodynamic wall shear stress (WSS). A recently-introduced metric, the transverse wall shear stress (transWSS), which is...