Sorin Istrail
Overview
Explore the profile of Sorin Istrail including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
1203
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0
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Recent Articles
11.
Atias N, Istrail S, Sharan R
Curr Opin Genet Dev
. 2013 Nov;
23(6):622-6.
PMID: 24209906
A holy grail of genetics is to decipher the mapping from genotype to phenotype. Recent advances in sequencing technologies allow the efficient genotyping of thousands of individuals carrying a particular...
12.
Gamsiz E, Viscidi E, Frederick A, Nagpal S, Sanders S, Murtha M, et al.
Am J Hum Genet
. 2013 Jul;
93(1):103-9.
PMID: 23830515
Intellectual disability (ID), often attributed to autosomal-recessive mutations, occurs in 40% of autism spectrum disorders (ASDs). For this reason, we conducted a genome-wide analysis of runs of homozygosity (ROH) in...
13.
Aguiar D, Istrail S
Bioinformatics
. 2013 Jul;
29(13):i352-60.
PMID: 23813004
Motivation: Genome-wide haplotype reconstruction from sequence data, or haplotype assembly, is at the center of major challenges in molecular biology and life sciences. For complex eukaryotic organisms like humans, the...
14.
Tulin S, Aguiar D, Istrail S, Smith J
Evodevo
. 2013 Jun;
4:16.
PMID: 23731568
Background: The de novo assembly of transcriptomes from short shotgun sequences raises challenges due to random and non-random sequencing biases and inherent transcript complexity. We sought to define a pipeline...
15.
Uzun A, DeWan A, Istrail S, Padbury J
Genomics
. 2013 Jan;
101(3):163-70.
PMID: 23298525
Preterm birth in the United States is now 12%. Multiple genes, gene networks, and variants have been associated with this disease. Using a custom database for preterm birth (dbPTB) with...
16.
Huang A, Kantor R, DeLong A, Schreier L, Istrail S
In Silico Biol
. 2012 Dec;
11(5-6):193-201.
PMID: 23202421
Next generation sequencing technologies have recently been applied to characterize mutational spectra of the heterogeneous population of viral genotypes (known as a quasispecies) within HIV-infected patients. Such information is clinically...
17.
Huang A, Hogan J, Istrail S, DeLong A, Katzenstein D, Kantor R
Future Virol
. 2012 Jul;
7(5):505-517.
PMID: 22822410
AIMS: HIV-1 sequence diversity can affect host immune responses and phenotypic characteristics such as antiretroviral drug resistance. Current HIV-1 sequence diversity classification uses phylogeny-based methods to identify subtypes and recombinants,...
18.
Aguiar D, Istrail S
J Comput Biol
. 2012 Jun;
19(6):577-90.
PMID: 22697235
Genome assembly methods produce haplotype phase ambiguous assemblies due to limitations in current sequencing technologies. Determining the haplotype phase of an individual is computationally challenging and experimentally expensive. However, haplotype...
19.
Aguiar D, Halldorsson B, Morrow E, Istrail S
Bioinformatics
. 2012 Jun;
28(12):i154-62.
PMID: 22689755
Motivation: The understanding of the genetic determinants of complex disease is undergoing a paradigm shift. Genetic heterogeneity of rare mutations with deleterious effects is more commonly being viewed as a...
20.
Uzun A, Laliberte A, Parker J, Andrew C, Winterrowd E, Sharma S, et al.
Database (Oxford)
. 2012 Feb;
2012:bar069.
PMID: 22323062
Genome-wide association studies (GWAS) query the entire genome in a hypothesis-free, unbiased manner. Since they have the potential for identifying novel genetic variants, they have become a very popular approach...