Sophie M Lehar
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Explore the profile of Sophie M Lehar including associated specialties, affiliations and a list of published articles.
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11
Citations
595
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Recent Articles
1.
Alicke B, Totpal K, Schartner J, Berkley A, Lehar S, Capietto A, et al.
J Immunother Cancer
. 2020 Jul;
8(2).
PMID: 32675310
The recent success of multiple immunomodulating drugs in oncology highlights the potential of relieving immunosuppression by directly engaging the immune system in the tumor bed to target cancer cells. Durable...
2.
Staben L, Koenig S, Lehar S, Vandlen R, Zhang D, Chuh J, et al.
Nat Chem
. 2016 Nov;
8(12):1112-1119.
PMID: 27874860
The reversible attachment of a small-molecule drug to a carrier for targeted delivery can improve pharmacokinetics and the therapeutic index. Previous studies have reported the delivery of molecules that contain...
3.
Lehar S, Pillow T, Xu M, Staben L, Kajihara K, Vandlen R, et al.
Nature
. 2015 Nov;
527(7578):323-8.
PMID: 26536114
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of...
4.
Coady A, Xu M, Phung Q, Cheung T, Bakalarski C, Alexander M, et al.
PLoS One
. 2015 Sep;
10(9):e0138350.
PMID: 26379037
Manganese plays a central role in cellular detoxification of reactive oxygen species (ROS). Therefore, manganese acquisition is considered to be important for bacterial pathogenesis by counteracting the oxidative burst of...
5.
Hazenbos W, Kajihara K, Vandlen R, Morisaki J, Lehar S, Kwakkenbos M, et al.
PLoS Pathog
. 2013 Oct;
9(10):e1003653.
PMID: 24130480
Infection of host tissues by Staphylococcus aureus and S. epidermidis requires an unusual family of staphylococcal adhesive proteins that contain long stretches of serine-aspartate dipeptide-repeats (SDR). The prototype member of...
6.
Sun J, Lehar S, Bevan M
J Immunol
. 2006 Sep;
177(7):4458-63.
PMID: 16982881
IL-7 signals are crucial for the survival of naive and memory T cells, and the IL-7R is expressed on the surface of these cells. Following viral infection, the IL-7R is...
7.
Lehar S, Bevan M
Mol Cell Biol
. 2006 Aug;
26(20):7358-71.
PMID: 16923970
Deltex1, Deltex2, and Deltex4 form a family of related proteins that are the mammalian homologues of Drosophila Deltex, a known regulator of Notch signals. Deltex1 is highly induced by Notch...
8.
Lehar S, Dooley J, Farr A, Bevan M
Blood
. 2004 Oct;
105(4):1440-7.
PMID: 15486060
Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2...
9.
10.
Huang E, Gallegos A, Richards S, Lehar S, Bevan M
J Immunol
. 2003 Aug;
171(5):2296-304.
PMID: 12928374
Notch1 plays a critical role in regulating T lineage commitment during the differentiation of lymphoid precursors. The physiological relevance of Notch1 signaling during subsequent stages of T cell differentiation has...