Sophie Lecher
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Explore the profile of Sophie Lecher including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
405
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Recent Articles
1.
Veyron-Churlet R, Lecher S, Lacoste A, Saliou J, Locht C
FASEB J
. 2023 Jun;
37(7):e23036.
PMID: 37331005
Cholesterol is a crucial component in Mycobacterium tuberculosis virulence as it is required for phagocytosis of mycobacteria by macrophages. In addition, the tubercle bacilli can grow using cholesterol as the...
2.
Large-Scale Conformational Changes of FhaC Provide Insights Into the Two-Partner Secretion Mechanism
Sicoli G, Konijnenberg A, Guerin J, Hessmann S, Del Nero E, Hernandez-Alba O, et al.
Front Mol Biosci
. 2022 Aug;
9:950871.
PMID: 35936790
The Two-Partner secretion pathway mediates protein transport across the outer membrane of Gram-negative bacteria. TpsB transporters belong to the Omp85 superfamily, whose members catalyze protein insertion into, or translocation across...
3.
Dupre E, Clantin B, Yuan Y, Lecher S, Lesne E, Antoine R, et al.
J Bacteriol
. 2021 Feb;
203(9).
PMID: 33619154
The two-component system BvgAS controls the virulence regulon in BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected...
4.
Corbiere V, Segers J, Desmet R, Lecher S, Loyens M, Petit E, et al.
J Immunol
. 2020 Mar;
204(7):1715-1723.
PMID: 32122997
T cell epitopes are mostly nonmodified peptides, although posttranslationally modified peptide epitopes have been described, but they originated from viral or self-proteins. In this study, we provide evidence of a...
5.
Debrie A, Mielcarek N, Lecher S, Roux X, Sirard J, Locht C
J Immunol
. 2019 Nov;
203(12):3293-3300.
PMID: 31732529
Pertussis is a severe respiratory disease mainly caused by Despite wide global vaccination coverage with efficacious pertussis vaccines, it remains one of the least well-controlled vaccine-preventable diseases, illustrating the shortcomings...
6.
Raze D, Segers J, Mille C, Slupek S, Lecher S, Coutte L, et al.
Mol Microbiol
. 2019 Oct;
113(1):52-67.
PMID: 31587365
The heparin-binding hemagglutinin (HBHA) is a multifunctional protein involved in adherence of Mycobacterium tuberculosis to non-phagocytic cells and in the formation of intracytosolic lipid inclusions. We demonstrate that the expression...
7.
Locht C, Papin J, Lecher S, Debrie A, Thalen M, Solovay K, et al.
J Infect Dis
. 2017 May;
216(1):117-124.
PMID: 28535276
Evidence suggests that the resurgence of pertussis in many industrialized countries may result from the failure of current vaccines to prevent nasopharyngeal colonization by Bordetella pertussis, the principal causative agent...
8.
Merker M, Blin C, Mona S, Duforet-Frebourg N, Lecher S, Willery E, et al.
Nat Genet
. 2015 Jan;
47(3):242-9.
PMID: 25599400
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and...
9.
HBHA vaccination may require both Th1 and Th17 immune responses to protect mice against tuberculosis
Verwaerde C, Debrie A, Dombu C, Legrand D, Raze D, Lecher S, et al.
Vaccine
. 2014 Sep;
32(47):6240-50.
PMID: 25252198
Almost one century after the discovery of the BCG vaccine, tuberculosis remains a major cause of global mortality and morbidity, emphasizing the urgent need to design more efficient vaccines. The...
10.
Dessein R, Corbiere V, Nortier J, Dratwa M, Gastaldello K, Pozdzik A, et al.
PLoS One
. 2013 Aug;
8(8):e71088.
PMID: 23940693
Background: Patients with end-stage renal disease (ESRD) and latently infected with Mycobacterium tuberculosis (LTBI) are at higher risk to develop tuberculosis (TB) than healthy subjects. Interferon-gamma release assays (IGRAs) were...