Sophie Astrof
Overview
Explore the profile of Sophie Astrof including associated specialties, affiliations and a list of published articles.
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29
Citations
598
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Recent Articles
1.
Arriagada C, Lin E, Schonning M, Astrof S
Dev Cell
. 2024 Oct;
60(1):62-84.e7.
PMID: 39413783
Failure in the elongation of the cardiac outflow tract (OFT) results in congenital heart disease due to the misalignment of the great arteries with the left and right ventricles. The...
2.
Ramirez A, Vyzas C, Zhao H, Eng K, Degenhardt K, Astrof S
Circ Res
. 2024 Apr;
134(10):e112-e132.
PMID: 38618720
Background: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting...
3.
Bhaskar A, Astrof S
bioRxiv
. 2024 Feb;
PMID: 38405938
The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro-computed tomography (micro-CT), the IMPC has created and...
4.
Ramirez A, Vyzas C, Zhao H, Eng K, Degenhardt K, Astrof S
bioRxiv
. 2024 Feb;
PMID: 38370627
Rationale: The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting...
5.
SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development
Alexander B, Zhao H, Astrof S
Dev Dyn
. 2023 Aug;
253(1):119-143.
PMID: 37650555
Background: During embryogenesis, cardiac neural crest-derived cells (NCs) migrate into the pharyngeal arches and give rise to the vascular smooth muscle cells (vSMCs) of the pharyngeal arch arteries (PAAs). vSMCs...
6.
Melamed S, Zaffryar-Eilot S, Nadjar-Boger E, Aviram R, Zhao H, Yaseen-Badarne W, et al.
Cell Rep
. 2023 May;
42(5):112473.
PMID: 37148241
Fibronectin fibrillogenesis and mechanosensing both depend on integrin-mediated force transmission to the extracellular matrix. However, force transmission is in itself dependent on fibrillogenesis, and fibronectin fibrils are found in soft...
7.
Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly R, Moon A
Dev Biol
. 2023 Apr;
499:10-21.
PMID: 37060937
Development of the outflow tract of the heart requires specification, proliferation and deployment of a progenitor cell population from the second heart field to generate the myocardium at the arterial...
8.
Alexander B, Zhao H, Astrof S
bioRxiv
. 2023 Mar;
PMID: 36993156
Background: The pharyngeal arch arteries (PAAs) are precursor vessels which remodel into the aortic arch arteries (AAAs) during embryonic cardiovascular development. Cardiac neural crest cells (NCs) populate the PAAs and...
9.
Tomer D, Arriagada C, Munshi S, Alexander B, French B, Vedula P, et al.
J Cell Sci
. 2022 Jul;
135(16).
PMID: 35851804
Fibronectin (Fn1) fibrils have long been viewed as continuous fibers composed of extended, periodically aligned Fn1 molecules. However, our live-imaging and single-molecule localization microscopy data are inconsistent with this traditional...
10.
Metikala S, Warkala M, Casie Chetty S, Chestnut B, Rufin Florat D, Plender E, et al.
Dev Cell
. 2022 Mar;
57(6):767-782.e6.
PMID: 35276066
During embryogenesis, the initial vascular network forms by the process of vasculogenesis, or the specification of vascular progenitors de novo. In contrast, the majority of later-forming vessels arise by angiogenesis...