Smaranda Bodea
Overview
Explore the profile of Smaranda Bodea including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
321
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0
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Recent Articles
1.
Ruprecht B, Wei L, Zheng L, Bodea S, Mo X, Maschberger M, et al.
Cell Chem Biol
. 2022 Nov;
29(11):1639-1648.e4.
PMID: 36356585
DNA-binding proteins are promising therapeutic targets but are notoriously difficult to drug. Here, we evaluate a chemoproteomic DNA interaction platform as a complementary strategy for parallelized compound profiling. To enable...
2.
Li X, Chandra D, Letarte S, Adam G, Welch J, Yang R, et al.
Anal Chem
. 2021 May;
93(23):8161-8169.
PMID: 34032423
Polysorbate is widely used to maintain stability of biotherapeutic proteins in pharmaceutical formulation development. Degradation of polysorbate can lead to particle formation in drug products, which is a major quality...
3.
Hart E, Mitchell A, Konovalova A, Grabowicz M, Sheng J, Han X, et al.
Proc Natl Acad Sci U S A
. 2019 Oct;
116(43):21748-21757.
PMID: 31591200
The development of new antimicrobial drugs is a priority to combat the increasing spread of multidrug-resistant bacteria. This development is especially problematic in gram-negative bacteria due to the outer membrane...
4.
Demma M, Mapelli C, Sun A, Bodea S, Ruprecht B, Javaid S, et al.
Mol Cell Biol
. 2019 Sep;
39(22).
PMID: 31501275
The MYC oncogene is upregulated in human cancers by translocation, amplification, and mutation of cellular pathways that regulate Myc. Myc/Max heterodimers bind to E box sequences in the promoter regions...
5.
Orman M, Bodea S, Funk M, Martinez-Del Campo A, Bollenbach M, Drennan C, et al.
J Am Chem Soc
. 2018 Dec;
141(1):33-37.
PMID: 30557011
The anaerobic gut microbial pathway that converts choline into trimethylamine (TMA) is broadly linked to human disease. Here, we describe the discovery that betaine aldehyde inhibits TMA production from choline...
6.
Purification and Characterization of the Choline Trimethylamine-Lyase (CutC)-Activating Protein CutD
Bodea S, Balskus E
Methods Enzymol
. 2018 Aug;
606:73-94.
PMID: 30097105
Anaerobic choline deamination catalyzed by the glycyl radical enzyme choline trimethylamine-lyase (CutC) has emerged as a major route for trimethylamine (TMA) production within anaerobic environments, including the human gut. The...
7.
Bodea S, Funk M, Balskus E, Drennan C
Cell Chem Biol
. 2016 Sep;
23(10):1206-1216.
PMID: 27642068
Deamination of choline catalyzed by the glycyl radical enzyme choline trimethylamine-lyase (CutC) has emerged as an important route for the production of trimethylamine, a microbial metabolite associated with both human...
8.
Martinez-Del Campo A, Bodea S, Hamer H, Marks J, Haiser H, Turnbaugh P, et al.
mBio
. 2015 Apr;
6(2).
PMID: 25873372
Unlabelled: Elucidation of the molecular mechanisms underlying the human gut microbiota's effects on health and disease has been complicated by difficulties in linking metabolic functions associated with the gut community...