Slava Ziegler
Overview
Explore the profile of Slava Ziegler including associated specialties, affiliations and a list of published articles.
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78
Citations
1083
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Recent Articles
1.
Binici A, Hennes E, Koska S, Alexander Niemann J, Reich A, Pfaff C, et al.
Chemistry
. 2025 Feb;
:e202404006.
PMID: 39932696
The tumor microenvironment (TME) is a pro-cancerous niche harboring immunosuppressive factors that are secreted by cancer cells and the surrounding cancer-supportive tissue, such as kynurenine, prostaglandin E2 and transforming growth...
2.
Hennes E, Lucas B, Scholes N, Cheng X, Scott D, Bischoff M, et al.
bioRxiv
. 2024 Jul;
PMID: 39026748
Targeted protein degradation (TPD) modulates protein function beyond inhibition of enzyme activity or protein-protein interactions. Most degrader drugs function by directly mediating proximity between a neosubstrate and hijacked E3 ligase....
3.
Rezaei Adariani S, Agne D, Koska S, Burhop A, Seitz C, Warmers J, et al.
J Med Chem
. 2024 Jul;
67(15):13252-13270.
PMID: 39018123
Mitochondria are cellular powerhouses and are crucial for cell function. However, they are vulnerable to internal and external perturbagens that may impair mitochondrial function and eventually lead to cell death....
4.
Patil S, Cremosnik G, Dotsch L, Flegel J, Schulte B, Maier K, et al.
Angew Chem Int Ed Engl
. 2024 May;
63(32):e202404645.
PMID: 38801173
Phenotypic assays detect small-molecule bioactivity at functionally relevant cellular sites, and inherently cover a variety of targets and mechanisms of action. They can uncover new small molecule-target pairs and may...
5.
Pahl A, Liu J, Patil S, Rezaei Adariani S, Scholermann B, Warmers J, et al.
J Med Chem
. 2024 Apr;
67(11):8862-8876.
PMID: 38687818
Screening for small-molecule modulators of disease-relevant targets and phenotypes is the first step on the way to new drugs. Large compound libraries have been synthesized by academia and, particularly, pharmaceutical...
6.
Wang L, Yilmaz F, Yildirim O, Scholermann B, Bag S, Greiner L, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(21):e2309202.
PMID: 38569218
The pseudo-natural product (pseudo-NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but...
7.
Dotsch L, Davies C, Hennes E, Schonfeld J, Kumar A, Guita C, et al.
J Med Chem
. 2024 Mar;
67(6):4691-4706.
PMID: 38470246
Disease-related phenotypic assays enable unbiased discovery of novel bioactive small molecules and may provide novel insights into physiological systems and unprecedented molecular modes of action (MMOA). Herein, we report the...
8.
Bag S, Liu J, Patil S, Bonowski J, Koska S, Scholermann B, et al.
Nat Chem
. 2024 Feb;
16(6):945-958.
PMID: 38365941
The efficient exploration of biologically relevant chemical space is essential for the discovery of bioactive compounds. A molecular design principle that possesses both biological relevance and structural diversity may more...
9.
Corkery D, Ursu A, Lucas B, Grigalunas M, Kriegler S, Oliva R, et al.
Chembiochem
. 2023 Oct;
24(24):e202300579.
PMID: 37869939
Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3-lipidation is also triggered by stimuli not related to canonical autophagy. Therefore, characterization of the...
10.
Xie J, Pahl A, Krzyzanowski A, Krupp A, Liu J, Koska S, et al.
Angew Chem Int Ed Engl
. 2023 Oct;
62(48):e202310222.
PMID: 37818743
Monoterpene indole alkaloids (MIAs) are endowed with high structural and spatial complexity and characterized by diverse biological activities. Given this complexity-activity combination in MIAs, rapid and efficient access to chemical...