Siw Johannesen
Overview
Explore the profile of Siw Johannesen including associated specialties, affiliations and a list of published articles.
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13
Citations
132
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Recent Articles
1.
Schuster J, Dreyhaupt J, Monkemoller K, Dupuis L, Dieterle S, Weishaupt J, et al.
Eur J Neurol
. 2024 Jan;
31(4):e16204.
PMID: 38240416
Background And Purpose: In 2016, we concluded a randomized controlled trial testing 1 mg rasagiline per day add-on to standard therapy in 252 amyotrophic lateral sclerosis (ALS) patients. This article...
2.
Kozole J, Heydn R, Wirkert E, Kuspert S, Aigner L, Bruun T, et al.
Pharmaceutics
. 2022 Sep;
14(9).
PMID: 36145606
The hematopoietic granulocyte-colony stimulating growth factor (G-CSF, filgrastim) is an approved drug in hematology and oncology. Filgrastim's potential in neurodegenerative disorders is gaining increasingly more attention, as preclinical and early...
3.
Peters S, Wirkert E, Kuespert S, Heydn R, Johannesen S, Friedrich A, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35057094
The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal...
4.
Peters S, Kuespert S, Wirkert E, Heydn R, Jurek B, Johannesen S, et al.
Neurotherapeutics
. 2021 Apr;
18(3):1963-1979.
PMID: 33860461
Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has...
5.
Johannesen S, Huie J, Budeus B, Peters S, Wirth A, Iberl S, et al.
Front Neurol
. 2021 Apr;
12:616289.
PMID: 33815246
Developing an integrative approach to early treatment response classification using survival modeling and bioinformatics with various biomarkers for early assessment of filgrastim (granulocyte colony stimulating factor) treatment effects in amyotrophic...
6.
Aschauer-Wallner S, Leis S, Bogdahn U, Johannesen S, Couillard-Despres S, Aigner L
Drug Discov Today
. 2021 Mar;
26(7):1642-1655.
PMID: 33781952
Granulocyte colony-stimulating factor (G-CSF) is a cytokine used in pharmaceutical preparations for the treatment of chemotherapy-induced neutropenia. Evidence from experimental studies indicates that G-CSF exerts relevant activities in the central...
7.
Kuespert S, Heydn R, Peters S, Wirkert E, Meyer A, Sieborger M, et al.
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32178467
Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable, and effective ASO drug candidate in locked nucleic acid (LNA)-gapmer design,...
8.
Iberl S, Meyer A, Muller G, Peters S, Johannesen S, Kobor I, et al.
Cytokine
. 2019 May;
120:192-201.
PMID: 31100684
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of complex and still poorly understood etiology. Loss of upper and lower motoneurons results in death within few years after diagnosis. Recent...
9.
Dorst J, Chen L, Rosenbohm A, Dreyhaupt J, Hubers A, Schuster J, et al.
J Neurol
. 2019 Mar;
266(6):1516-1525.
PMID: 30923935
Objective: Several independent prognostic factors, such as age of onset, type of onset, body mass index (BMI), and progression rate have been identified for amyotrophic lateral sclerosis (ALS) in Caucasians....
10.
Wirth A, Johannesen S, Khomenko A, Baldaranov D, Bruun T, Wendl C, et al.
J Magn Reson Imaging
. 2018 Dec;
50(2):552-559.
PMID: 30569457
Background: MRI fluid-attenuated inversion recovery (FLAIR) studies reported hyperintensity in the corticospinal tract and corpus callosum of patients with amyotrophic lateral sclerosis (ALS). Purpose: To evaluate the lesion segmentation toolbox...