Sivakumar Vallabhapurapu
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Explore the profile of Sivakumar Vallabhapurapu including associated specialties, affiliations and a list of published articles.
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10
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3230
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Recent Articles
1.
Sarvagalla S, Kolapalli S, Vallabhapurapu S
Front Oncol
. 2019 Dec;
9:1230.
PMID: 31824839
Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair,...
2.
Vallabhapurapu S, Noothi S, Pullum D, Lawrie C, Pallapati R, Potluri V, et al.
Nat Commun
. 2015 Oct;
6:8428.
PMID: 26455434
Although transcriptional activation by NF-κB is well appreciated, physiological importance of transcriptional repression by NF-κB in cancer has remained elusive. Here we show that an HDAC4-RelB-p52 complex maintains repressive chromatin...
3.
Jaganathan S, Malek E, Vallabhapurapu S, Vallabhapurapu S, Driscoll J
Oncotarget
. 2014 Dec;
5(23):12358-70.
PMID: 25481044
The proteasome inhibitor bortezomib is an effective anti-cancer agent for the plasma cell malignancy multiple myeloma but clinical response is hindered by the emergence of drug resistance through unknown mechanisms....
4.
Potluri V, Noothi S, Vallabhapurapu S, Yoon S, Driscoll J, Lawrie C, et al.
PLoS One
. 2013 Jul;
8(7):e66121.
PMID: 23874387
Multiple Myeloma (MM) is an incurable plasma cell cancer that is caused by several chromosomal translocations and gene deletions. Although deregulation of several signaling pathways including the Nuclear Factor-Kappa B...
5.
de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, et al.
Immunity
. 2010 Sep;
33(3):400-11.
PMID: 20832341
Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) functions downstream of multiple TNF receptors and receptors that induce interferon-α (IFN-α), IFN-β, and IFN-λ production, including Toll-like receptor 3 (TLR3), which...
6.
Vallabhapurapu S, Karin M
Annu Rev Immunol
. 2009 Mar;
27:693-733.
PMID: 19302050
The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the...
7.
Grivennikov S, Karin E, Terzic J, Mucida D, Yu G, Vallabhapurapu S, et al.
Cancer Cell
. 2009 Feb;
15(2):103-13.
PMID: 19185845
Colitis-associated cancer (CAC) is the most serious complication of inflammatory bowel disease. Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC tumorigenesis. Interleukin 6 (IL-6) is a multifunctional...
8.
Vallabhapurapu S, Powolny-Budnicka I, Riemann M, Schmid R, Paxian S, Pfeffer K, et al.
Eur J Immunol
. 2008 Nov;
38(12):3508-19.
PMID: 19003818
Development of NKT cells was shown to depend on lymphotoxin (LT) and IL-15 signaling pathways as well as on cytokine receptor common gamma chain. After positive selection, NKT-cell precursors transit...
9.
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng P, Keats J, Wang H, et al.
Nat Immunol
. 2008 Nov;
9(12):1364-70.
PMID: 18997792
The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-kappaB (NF-kappaB) signaling in resting cells by targeting NF-kappaB-inducing kinase (NIK) for ubiquitin-dependent degradation, thus preventing...
10.
Matsuzawa A, Tseng P, Vallabhapurapu S, Luo J, Zhang W, Wang H, et al.
Science
. 2008 Jul;
321(5889):663-8.
PMID: 18635759
Cytokine signaling is thought to require assembly of multicomponent signaling complexes at cytoplasmic segments of membrane-embedded receptors, in which receptor-proximal protein kinases are activated. Indeed, CD40, a tumor necrosis factor...