Simon T C Peake
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Explore the profile of Simon T C Peake including associated specialties, affiliations and a list of published articles.
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12
Citations
276
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Recent Articles
1.
Bernardo D, Durant L, Mann E, Bassity E, Montalvillo E, Man R, et al.
Cell Mol Gastroenterol Hepatol
. 2016 Feb;
2(1):22-39.e5.
PMID: 26866054
Background & Aims: Most knowledge about gastrointestinal (GI)-tract dendritic cells (DC) relies on murine studies where CD103 DC specialize in generating immune tolerance with the functionality of CD11b subsets being...
2.
Mann E, Bernardo D, English N, Landy J, Al-Hassi H, Peake S, et al.
Gut
. 2015 Feb;
65(2):256-70.
PMID: 25666191
Objective: Dendritic cells (DC) mediate intestinal immune tolerance. Despite striking differences between the colon and the ileum both in function and bacterial load, few studies distinguish between properties of immune...
3.
Mann E, Bernardo D, Ng S, Rigby R, Al-Hassi H, Landy J, et al.
Inflamm Bowel Dis
. 2014 Nov;
20(12):2299-307.
PMID: 25397892
: The pathogenesis of inflammatory bowel disease is incompletely understood but results from a dysregulated intestinal immune response to the luminal microbiota. CD4 T cells mediate tissue injury in the...
4.
Al-Hassi H, Mann E, Sanchez B, English N, Peake S, Landy J, et al.
Mol Nutr Food Res
. 2013 Dec;
58(5):1132-43.
PMID: 24347371
Scope: The human/microbiota cross-talk is partially mediated by bacteria-derived peptides like Serine-Threonine peptide (STp), which is resistant to gut proteolysis, is found in the human healthy colon and induces regulatory...
5.
Landy J, Wahed M, Peake S, Hussein M, Ng S, Lindsay J, et al.
J Crohns Colitis
. 2013 Apr;
7(11):e516-21.
PMID: 23623737
Background: The medical management of refractory ulcerative colitis (UC) remains a significant challenge. Two randomised controlled studies have demonstrated tacrolimus therapy is effective for the induction of remission of moderate...
6.
Peake S, Bernardo D, Mann E, Al-Hassi H, Knight S, Hart A
Inflamm Bowel Dis
. 2013 Apr;
19(7):1546-55.
PMID: 23594837
Crohn's disease (CD) is characterized by inflammation that can affect any part of the gastrointestinal tract. It is a chronic destructive condition that follows a relapsing-remitting course and can lead...
7.
Mann E, Landy J, Bernardo D, Peake S, Hart A, Al-Hassi H, et al.
Immunol Lett
. 2013 Jan;
150(1-2):30-40.
PMID: 23352670
The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and...
8.
Bernardo D, Vallejo-Diez S, Mann E, Al-Hassi H, Martinez-Abad B, Montalvillo E, et al.
Eur J Immunol
. 2012 Apr;
42(5):1337-53.
PMID: 22539302
Dendritic cells (DCs) control the type and location of immune responses. Ulcerative colitis (UC) is considered a Th2 disease mediated by IL-13 where up to one third of patients can...
9.
Bernardo D, Al-Hassi H, Mann E, Tee C, Murugananthan A, Peake S, et al.
Hum Immunol
. 2012 Jan;
73(3):223-31.
PMID: 22248741
T-cell proliferation rates in vitro depend on factors including initial T-cell number, dose of stimulus, culture time, and available physical space. The role of forkhead box P3 (FoxP3) in the...
10.
Culkin A, Gabe S, Peake S, Stern J
Int J Eat Disord
. 2011 Mar;
45(2):302-4.
PMID: 21433049
We present a 36-year-old female diagnosed with Crohn's disease at the age of 11 years. In 2001, she underwent a total colectomy and further small bowel resection as a result...