Simon Sanggaard
Overview
Explore the profile of Simon Sanggaard including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
692
Followers
0
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Recent Articles
1.
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, et al.
J Cereb Blood Flow Metab
. 2023 Jun;
43(11):1891-1904.
PMID: 37340791
Carbon dioxide (CO) is traditionally considered as metabolic waste, yet its regulation is critical for brain function. It is well accepted that hypercapnia initiates vasodilation, but its effect on neuronal...
2.
Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, et al.
Sci Rep
. 2020 Feb;
10(1):3934.
PMID: 32107453
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Koundal S, Elkin R, Nadeem S, Xue Y, Constantinou S, Sanggaard S, et al.
Sci Rep
. 2020 Feb;
10(1):1990.
PMID: 32029859
The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid (CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport solutes and clear waste from brain....
4.
Mortensen K, Sanggaard S, Mestre H, Lee H, Kostrikov S, L R Xavier A, et al.
J Neurosci
. 2019 Jun;
39(32):6365-6377.
PMID: 31209176
The glymphatic system is a brainwide CSF transport system that uses the perivascular space for fast inflow of CSF. Arterial pulsations are a major driver of glymphatic CSF inflow, and...
5.
Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, et al.
Neuroscience
. 2019 Jan;
404:14-26.
PMID: 30690138
Cerebral small vessel disease(s) (SVD) results from pathological changes of the small blood vessels in the brain and is common in older people. The diagnostic features by which SVD manifests...
6.
Benveniste H, Liu X, Koundal S, Sanggaard S, Lee H, Wardlaw J
Gerontology
. 2018 Jul;
65(2):106-119.
PMID: 29996134
The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic products. Specifically, the glymphatic...
7.
L R Xavier A, Hauglund N, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, et al.
J Vis Exp
. 2018 Jun;
(135).
PMID: 29889209
Cisterna magna cannulation (CMc) is a straightforward procedure that enables direct access to the cerebrospinal fluid (CSF) without operative damage to the skull or the brain parenchyma. In anesthetized rodents,...
8.
Lee H, Mortensen K, Sanggaard S, Koch P, Brunner H, Quistorff B, et al.
Magn Reson Med
. 2017 Jun;
79(3):1568-1578.
PMID: 28627037
Purpose: We propose a quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast-enhanced MRI (DCE-MRI). With this approach, a small molecular weight paramagnetic contrast agent...
9.
Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell J, et al.
Nat Commun
. 2015 Apr;
6:6807.
PMID: 25904018
Metabolically, the brain is a highly active organ that relies almost exclusively on glucose as its energy source. According to the astrocyte-to-neuron lactate shuttle hypothesis, glucose is taken up by...