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Simon Rosenfeld

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Articles 17
Citations 127
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Recent Articles
1.
Rosenfeld S
Cancer Inform . 2013 Dec; 12:221-9. PMID: 24324325
Two drastically different approaches to understanding the forces driving carcinogenesis have crystallized through years of research. These are the somatic mutation theory (SMT) and the tissue organization field theory (TOFT)....
2.
Rosenfeld S
Gene Regul Syst Bio . 2013 Mar; 7:23-39. PMID: 23471309
Complex biological systems manifest a large variety of emergent phenomena among which prominent roles belong to self-organization and swarm intelligence. Generally, each level in a biological hierarchy possesses its own...
3.
Pepper J, Rosenfeld S
Trends Ecol Evol . 2012 Apr; 27(7):381-4. PMID: 22537667
It is increasingly clear that the human gut microbiome has great medical importance, and researchers are beginning to investigate its basic biology and to appreciate the challenges that it presents...
4.
Rosenfeld S
Gene Regul Syst Bio . 2012 Jan; 5:89-104. PMID: 22272063
Robustness has been long recognized to be a distinctive property of living entities. While a reasonably wide consensus has been achieved regarding the conceptual meaning of robustness, the biomolecular mechanisms...
5.
Rosenfeld S
Gene Regul Syst Bio . 2011 Apr; 5:27-40. PMID: 21523248
In this paper, a new model of self-organized criticality is introduced. This model, called the gene expression paradigm, is motivated by the problem of gene expression initiation in the newly-born...
6.
Rosenfeld S
Prog Biophys Mol Biol . 2011 Mar; 106(2):400-9. PMID: 21419158
In this paper, we review some fundamental aspects, as well as some new developments, in the emerging field of network biology. The focus of attention is placed on mathematical approaches...
7.
Rosenfeld S
Gene Regul Syst Bio . 2010 Jul; 4:61-73. PMID: 20628535
Poor reproducibility of microarray measurements is a major obstacle to their application as an instrument for clinical diagnostics. In this paper, several aspects of poor reproducibility are analyzed. All of...
8.
Rosenfeld S
Gene Regul Syst Bio . 2010 Jan; 3:159-79. PMID: 20054406
Microarray measurements of mRNA abundances is a standard tool for evaluation of transcriptional activity in functional genomics. The methodology underlying these measurements assumes existence of a direct link between transcription...
9.
Rosenfeld S
Gene Regul Syst Bio . 2009 Oct; 3:1-10. PMID: 19838330
The question of dynamical stability and stochastic behavior of large biochemical networks is discussed. It is argued that stringent conditions of asymptotic stability have very little chance to materialize in...
10.
Rosenfeld S, Kapetanovic I
Gene Regul Syst Bio . 2009 Sep; 2:307-19. PMID: 19787092
In this paper, we outline the status quo and approaches to further development of the systems biology concepts with focus on applications in cancer prevention science. We discuss the biological...