Simon Preston
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Explore the profile of Simon Preston including associated specialties, affiliations and a list of published articles.
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21
Citations
1767
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Recent Articles
1.
Li D, Heffernan K, Koch F, Peake D, Pascovici D, David M, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519111
The development of a sensitive and specific blood test for the early detection of breast cancer is crucial to improve screening and patient outcomes. Existing methods, such as mammography, have...
2.
Di Pietro A, Polmear J, Cooper L, Damelang T, Hussain T, Hailes L, et al.
Nat Immunol
. 2021 Nov;
23(1):86-98.
PMID: 34845392
Ineffective antibody-mediated responses are a key characteristic of chronic viral infection. However, our understanding of the intrinsic mechanisms that drive this dysregulation are unclear. Here, we identify that targeting the...
3.
Broad J, Preston S, Wheatley R, Graham R
J Chem Phys
. 2021 Oct;
155(14):144106.
PMID: 34654292
A strategy is outlined to reduce the number of training points required to model intermolecular potentials using Gaussian processes, without reducing accuracy. An asymptotic function is used at a long...
4.
Zhan Y, Zhang Y, Zhang S, Coughlan H, Baldoni P, Jacquelot N, et al.
Sci Immunol
. 2021 Sep;
6(63):eabf7268.
PMID: 34533976
Dendritic cells (DCs) and macrophages are at the forefront of immune responses, modifying their transcriptional programs in response to their tissue environment or immunological challenge. Posttranslational modifications of histones, such...
5.
Haque M, King J, Preston S, Loose M, Pomerai D
Math Biosci Eng
. 2020 Sep;
17(4):2881-2904.
PMID: 32987505
MicroRNAs are known to regulate gene expression either by repressing translation or by directing sequence-specific degradation of target mRNAs, and are therefore considered to be key regulators of gene expression....
6.
Baskin T, Preston S, Zelinsky E, Yang X, Elmali M, Bellos D, et al.
iScience
. 2020 Jul;
23(7):101309.
PMID: 32645582
In the root, meristem and elongation zone lengths remain stable, despite growth and division of cells. To gain insight into zone stability, we imaged individual Arabidopsis thaliana roots through a...
7.
Cooney J, Allison C, Preston S, Pellegrini M
J Leukoc Biol
. 2018 Jan;
103(2):287-293.
PMID: 29345371
Most persistent viral infections can be controlled, but not cured, by current therapies. Abrogated antiviral immunity and stable latently infected cells represent major barriers to cure. This necessitates life-long suppressive...
8.
Man K, Gabriel S, Liao Y, Gloury R, Preston S, Henstridge D, et al.
Immunity
. 2017 Dec;
47(6):1129-1141.e5.
PMID: 29246443
During chronic stimulation, CD8 T cells acquire an exhausted phenotype characterized by expression of inhibitory receptors, down-modulation of effector function, and metabolic impairments. T cell exhaustion protects from excessive immunopathology...
9.
Stutz M, Ojaimi S, Allison C, Preston S, Arandjelovic P, Hildebrand J, et al.
Cell Death Differ
. 2017 Dec;
25(5):951-965.
PMID: 29229989
Mixed lineage kinase domain-like (MLKL)-dependent necroptosis is thought to be implicated in the death of mycobacteria-infected macrophages, reportedly allowing escape and dissemination of the microorganism. Given the consequent interest in...
10.
Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, et al.
Nat Commun
. 2017 Oct;
8(1):1028.
PMID: 29044097
The Tet-On/Off system for conditional transgene expression constitutes state-of-the-art technology to study gene function by facilitating inducible expression in a timed and reversible manner. Several studies documented the suitability and...