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Simon Milling

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Articles 69
Citations 1159
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Recent Articles
1.
Adams L, Rasid O, Hulme H, Quon T, Burchmore R, Milling S, et al.
FASEB J . 2025 Feb; 39(4):e70415. PMID: 39989432
Inflammatory bowel disease (IBD) is a multifactorial disease, and patients frequently experience extraintestinal manifestations affecting multiple sites. Causes of systemic inflammation remain poorly understood, but molecules originating from the intestine...
2.
Milling S, Zeeshan Ijaz U, Venieri D, Christidis G, Rattray N, Gounaki I, et al.
PLoS One . 2024 Dec; 19(12):e0313090. PMID: 39689103
The experiments presented here are based on the reconfiguration of an ancient medicine, Lemnian Earth (LE) (terra sigillata, stamped earth, sphragis), an acclaimed therapeutic clay with a 2500-year history of...
3.
MacDonald L, Elmesmari A, Somma D, Frew J, Di Mario C, Madhu R, et al.
Immunity . 2024 Nov; 57(12):2843-2862.e12. PMID: 39609125
Current rheumatoid arthritis (RA) treatments do not restore immune tolerance. Investigating dendritic cell (DC) populations in human synovial tissue (ST) may reveal pathways to reinstate tolerance in RA. Using single-cell...
4.
Andrusaite A, Lewis J, Frede A, Farthing A, Kastele V, Montgomery J, et al.
Mucosal Immunol . 2024 Aug; 17(6):1199-1211. PMID: 39142634
Conventional dendritic cells (cDC) are central to maintaining the balance between protective immune responses and tolerance to harmless antigens, especially in the intestine. Short chain fatty acids (SCFAs) such as...
5.
Kerbiriou C, Dickson C, Nichols B, Logan M, Mascellani A, Havlik J, et al.
Inflamm Bowel Dis . 2024 Jul; 30(12):2457-2466. PMID: 38982655
Background: Exclusive enteral nutrition (EEN) is an effective treatment for active Crohn's disease (CD). This study explored the immunostimulatory potential of a cell-free fecal filtrate and related this with changes...
6.
Pan P, Wang Y, Nyirenda M, Saiyed Z, Karimian Azari E, Sunderman A, et al.
Commun Biol . 2024 Jul; 7(1):804. PMID: 38961129
Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the gastrointestinal tract to tolerate exposure to food and commensal...
7.
White B, Svolos V, Gervais L, Jatkowska A, Nichols B, MacDonald J, et al.
Inflamm Bowel Dis . 2024 Jun; 31(3):733-745. PMID: 38920313
Background: The immunological effects of treatment with exclusive enteral nutrition (EEN) in Crohn's disease (CD) remain unknown. We characterized the plasma levels of inflammation-related proteins (IRPs) in children with CD...
8.
White B, Curle J, Gervais L, Wands D, Nichols B, Hansen R, et al.
J Pediatr Gastroenterol Nutr . 2024 May; 79(1):148-153. PMID: 38779951
The immunological effects of exclusive enteral nutrition (EEN) in the treatment of active Crohn's disease (CD) are yet to be unveiled. The present study investigated changes in peripheral blood mononuclear...
9.
Nichols B, Briola A, Logan M, Havlik J, Mascellani A, Gkikas K, et al.
Am J Clin Nutr . 2024 Apr; 119(4):885-895. PMID: 38569785
Background: Predicting response to exclusive enteral nutrition (EEN) in active Crohn's disease (CD) could lead to therapy personalization and pretreatment optimization. Objectives: This study aimed to explore the ability of...
10.
Nair R, Lannagan T, Jackstadt R, Andrusaite A, Cole J, Boyne C, et al.
Oncoimmunology . 2024 Mar; 13(1):2330194. PMID: 38516270
Colorectal cancer (CRC) is the third most prevalent cancer worldwide with a high mortality rate (20-30%), especially due to metastasis to adjacent organs. Clinical responses to chemotherapy, radiation, targeted and...