Simon J Webb
Overview
Explore the profile of Simon J Webb including associated specialties, affiliations and a list of published articles.
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64
Citations
490
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Recent Articles
1.
Zubair I, Martinez-Crespo L, Webb S
Curr Opin Chem Biol
. 2024 Dec;
84:102549.
PMID: 39616809
Crucial physiological processes, like neural communication and muscle contraction, are mediated by protein channels in cell membranes. These natural channels typically have a central hydrophilic pore with tightly defined dimensions,...
2.
Tilly D, Heeb J, Webb S, Clayden J
Nat Commun
. 2024 Oct;
15(1):9327.
PMID: 39472554
No abstract available.
3.
Martinez-Crespo L, Whitehead G, Vitorica-Yrezabal I, Webb S
Chem Sci
. 2024 Sep;
PMID: 39345772
The structural, self-assembly and binding properties of oligo-(phenylene-ethynylene) (OPE) rigid rods linked to squaramides (SQs) have been studied and correlated with rod length. In the solid-state, OPE-SQ conjugates form indefinite...
4.
Doerner B, Della Sala F, Wang S, Webb S
Angew Chem Int Ed Engl
. 2024 May;
63(30):e202405924.
PMID: 38703400
Natural membrane receptors are proteins that can report on changes in the concentration of external chemical messengers. Messenger binding to a receptor produces conformational changes that are relayed through the...
5.
Tilly D, McColl C, Hu M, Vitorica-Yrezabal I, Webb S
Org Biomol Chem
. 2023 Nov;
21(48):9562-9571.
PMID: 38009076
Two short pentapeptides rich in α-aminoisobutyric acid (Aib) residues have been shown to act as enantioselective organocatalysts for the conjugate addition of nucleophiles to nitroolefins. An L-alanine terminated peptide, (Aib)(L-Ala)NHBu,...
6.
Martinez-Crespo L, Vitorica-Yrezabal I, Whitehead G, Webb S
Angew Chem Int Ed Engl
. 2023 Jul;
62(38):e202307841.
PMID: 37429824
Relaying conformational change over several nanometers is central to the function of allosterically regulated proteins. Replicating this mechanism artificially would provide important communication tools, but requires nanometer-sized molecules that reversibly...
7.
Al Nasser H, Martinez-Crespo L, Webb S, Dryfe R
Phys Chem Chem Phys
. 2023 Jun;
25(27):18121-18131.
PMID: 37382482
Thiourea-based receptors for anions have been widely studied due to their ability to transport anions across phospholipid bilayers. The binding affinity of a tripodal thiourea-based receptor for anions was assessed...
8.
Tilly D, Heeb J, Webb S, Clayden J
Nat Commun
. 2023 May;
14(1):2647.
PMID: 37156760
Molecular biology achieves control over complex reaction networks by means of molecular systems that translate a chemical input (such as ligand binding) into an orthogonal chemical output (such as acylation...
9.
Wang S, Della Sala F, Cliff M, Whitehead G, Vitorica-Yrezabal I, Webb S
J Am Chem Soc
. 2022 Nov;
144(47):21648-21657.
PMID: 36379007
Understanding and controlling peptide foldamer conformation in phospholipid bilayers is a key step toward their use as molecular information relays in membranes. To this end, a new F "reporter" tag...
10.
Fallows T, McGrath A, Silva J, McAdams S, Marchesi A, Tuna F, et al.
Nanoscale Adv
. 2022 Sep;
1(9):3597-3606.
PMID: 36133529
There is a need for biofunctionalised magnetic nanoparticles for many biomedical applications, including MRI contrast agents that have a range of surface properties and functional groups. A library of eleven...