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Simon Hippenmeyer

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Recent Articles
21.
Contreras X, Amberg N, Davaatseren A, Hansen A, Sonntag J, Andersen L, et al.
Cell Rep . 2021 Jun; 35(12):109274. PMID: 34161767
Mosaic analysis with double markers (MADM) offers one approach to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM applications include the analysis of lineage, single-cell...
22.
Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, et al.
Nat Commun . 2021 Jun; 12(1):3804. PMID: 34155196
In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However,...
23.
Zhang T, Liu T, Mora N, Guegan J, Bertrand M, Contreras X, et al.
Cell Rep . 2021 Jun; 35(10):109208. PMID: 34107249
Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory...
24.
Pauler F, Hudson Q, Laukoter S, Hippenmeyer S
Neurochem Int . 2021 Feb; 145:104986. PMID: 33600873
Genomic imprinting is an epigenetic mechanism that results in parental allele-specific expression of ~1% of all genes in mouse and human. Imprinted genes are key developmental regulators and play pivotal...
25.
Hanganu-Opatz I, Butt S, Hippenmeyer S, De Marco Garcia N, Cardin J, Voytek B, et al.
J Neurosci . 2021 Jan; 41(5):813-822. PMID: 33431633
The sensory and cognitive abilities of the mammalian neocortex are underpinned by intricate columnar and laminar circuits formed from an array of diverse neuronal populations. One approach to determining how...
26.
Laukoter S, Amberg N, Pauler F, Hippenmeyer S
STAR Protoc . 2020 Dec; 1(3):100215. PMID: 33377108
Mosaic analysis with double markers (MADM) technology enables concomitant fluorescent cell labeling and induction of uniparental chromosome disomy (UPD) with single-cell resolution. In UPD, imprinted genes are either overexpressed 2-fold...
27.
Takeo Y, Shuster S, Jiang L, Hu M, Luginbuhl D, Rulicke T, et al.
Neuron . 2020 Dec; 109(4):629-644.e8. PMID: 33352118
The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, but this hypothesis has not been causally tested in vivo in the mammalian brain. The presynaptic ligand cerebellin-1 (Cbln1) and...
28.
Zhang X, Mennicke C, Xiao G, Beattie R, Haider M, Hippenmeyer S, et al.
Cells . 2020 Dec; 9(12). PMID: 33322301
Development of the nervous system undergoes important transitions, including one from neurogenesis to gliogenesis which occurs late during embryonic gestation. Here we report on clonal analysis of gliogenesis in mice...
29.
Tian A, Kang B, Li B, Qiu B, Jiang W, Shao F, et al.
Adv Sci (Weinh) . 2020 Nov; 7(21):2001724. PMID: 33173731
Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the...
30.
Hansen A, Hippenmeyer S
Front Cell Dev Biol . 2020 Oct; 8:574382. PMID: 33102480
Concerted radial migration of newly born cortical projection neurons, from their birthplace to their final target lamina, is a key step in the assembly of the cerebral cortex. The cellular...