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Simon Hametner

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Articles 65
Citations 2437
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Recent Articles
1.
Abbadessa G, Nagano A, Hametner S, Howell O, Owen D, Papadaki A, et al.
Ann Neurol . 2025 Feb; PMID: 39949311
Objectives: Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a...
2.
Reeves J, Salman F, Mohebbi M, Bergsland N, Jakimovski D, Hametner S, et al.
Mult Scler Relat Disord . 2024 Dec; 93:106187. PMID: 39644585
Background: The deep gray matter (DGM), especially the pulvinar, and the white matter surrounding chronic active lesions have demonstrated depleted iron levels, indicating a possible mechanistic link. However, no studies...
3.
Lerma-Martin C, Badia-I-Mompel P, Ramirez Flores R, Sekol P, Schafer P, Riedl C, et al.
Nat Neurosci . 2024 Nov; 27(12):2354-2365. PMID: 39501036
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compartmentalized and restricted to specific tissue niches such as the lesion rim. However, the...
4.
Ludwig N, Cucinelli S, Hametner S, Muckenthaler M, Schirmer L
Trends Immunol . 2024 Jul; 45(8):625-638. PMID: 39054114
Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis...
5.
Bormann D, Knoflach M, Poreba E, Riedl C, Testa G, Orset C, et al.
Nat Commun . 2024 Jul; 15(1):6232. PMID: 39043661
Neuroglia critically shape the brain´s response to ischemic stroke. However, their phenotypic heterogeneity impedes a holistic understanding of the cellular composition of the early ischemic lesion. Here we present a...
6.
Calabrese M, Preziosa P, Scalfari A, Colato E, Marastoni D, Absinta M, et al.
Ann Neurol . 2024 Apr; 96(1):1-20. PMID: 38568026
Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a smoldering inflammatory activity is present from the earliest stages of the disease and underlies the progression of disability,...
7.
Kastrati K, Lotfi N, Tawfik M, Gelpi E, Hametner S, Hoftberger R, et al.
J Autoimmun . 2024 Mar; 144:103185. PMID: 38428109
Background: The significance of muscle biopsy as a diagnostic tool in idiopathic inflammatory myopathies (IIM) remains elusive. We aimed to determine the diagnostic weight that has been given to muscle...
8.
Guo Y, Endmayr V, Zekeridou A, McKeon A, Leypoldt F, Hess K, et al.
Acta Neuropathol . 2024 Feb; 147(1):31. PMID: 38310187
Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by the presence of anti-GFAP autoantibodies in the cerebrospinal fluid and...
9.
Steinmaurer A, Riedl C, Konig T, Testa G, Kock U, Bauer J, et al.
Brain Pathol . 2024 Jan; 34(5):e13240. PMID: 38254312
Activation of Bruton's tyrosine kinase (BTK) has been shown to play a crucial role in the proinflammatory response of B cells and myeloid cells upon engagement with B cell, Fc,...
10.
Bormann D, Knoflach M, Poreba E, Riedl C, Testa G, Orset C, et al.
bioRxiv . 2024 Jan; PMID: 38234821
Reactive neuroglia critically shape the braińs response to ischemic stroke. However, their phenotypic heterogeneity impedes a holistic understanding of the cellular composition and microenvironment of the early ischemic lesion. Here...