Simon Halegoua
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Explore the profile of Simon Halegoua including associated specialties, affiliations and a list of published articles.
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10
Citations
483
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Recent Articles
1.
Park J, Halegoua S, Kishida S, Neiman A
PLoS One
. 2015 Apr;
10(4):e0124836.
PMID: 25915401
The Vps13 protein family is highly conserved in eukaryotic cells. In humans, mutations in the gene encoding the family member VPS13A lead to the neurodegenerative disorder chorea-acanthocytosis. In the yeast...
2.
Harrington A, St Hillaire C, Zweifel L, Glebova N, Philippidou P, Halegoua S, et al.
Cell
. 2011 Aug;
146(3):421-34.
PMID: 21816277
The neurotrophins NGF and NT3 collaborate to support development of sympathetic neurons. Although both promote axonal extension via the TrkA receptor, only NGF activates retrograde transport of TrkA endosomes to...
3.
Philippidou P, Valdez G, Akmentin W, Bowers W, Federoff H, Halegoua S
Proc Natl Acad Sci U S A
. 2010 Dec;
108(2):852-7.
PMID: 21187387
Target-derived neurotrophins use retrogradely transported Trk-signaling endosomes to promote survival and neuronal phenotype at the soma. Despite their critical role in neurotrophin signaling, the nature and molecular composition of these...
4.
Schecterson L, Hudson M, Ko M, Philippidou P, Akmentin W, Wiley J, et al.
Mol Cell Neurosci
. 2010 Feb;
43(4):403-13.
PMID: 20123019
Activation of nascent receptor tyrosine kinases within the secretory pathway has been reported, yet the consequences of intracellular activation are largely unexplored. We report that overexpression of the Trk neurotrophin...
5.
Joset A, Dodd D, Halegoua S, Schwab M
J Cell Biol
. 2010 Jan;
188(2):271-85.
PMID: 20083601
Nogo-A is one of the most potent myelin-associated inhibitors for axonal growth, regeneration, and plasticity in the adult central nervous system. The Nogo-A-specific fragment NogoDelta20 induces growth cone collapse, and...
6.
Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones
Bonanomi D, Fornasiero E, Valdez G, Halegoua S, Benfenati F, Menegon A, et al.
J Cell Sci
. 2008 Oct;
121(Pt 22):3757-69.
PMID: 18940911
The growth-cone plasma membrane constantly reconfigures during axon navigation and upon target recognition. The identity and regulation of the membrane pathway(s) participating in remodeling of the growth-cone surface remain elusive....
7.
Valdez G, Philippidou P, Rosenbaum J, Akmentin W, Shao Y, Halegoua S
Proc Natl Acad Sci U S A
. 2007 Jul;
104(30):12270-5.
PMID: 17640889
Why neurotrophins and their Trk receptors promote neuronal differentiation and survival whereas receptor tyrosine kinases for other growth factors, such as EGF, do not, has been a long-standing question in...
8.
Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J, et al.
Curr Biol
. 2006 Nov;
16(21):2173-9.
PMID: 17084704
The RTK-Ras-ERK cascade is a central signaling module implicated in the control of diverse biological processes including cell proliferation, differentiation, and survival. The coupling of RTK to Ras is mediated...
9.
Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty D, Halegoua S
J Neurosci
. 2005 May;
25(21):5236-47.
PMID: 15917464
Retrograde signaling by neurotrophins is crucial for regulating neuronal phenotype and survival. The mechanism responsible for retrograde signaling has been elusive, because the molecular entities that propagate Trk receptor tyrosine...
10.
Shao Y, Akmentin W, Toledo-Aral J, Rosenbaum J, Valdez G, Cabot J, et al.
J Cell Biol
. 2002 May;
157(4):679-91.
PMID: 12011113
A central tenet of nerve growth factor (NGF) action that is poorly understood is its ability to mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve...