Simon H Pearce
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Explore the profile of Simon H Pearce including associated specialties, affiliations and a list of published articles.
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34
Citations
1121
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Recent Articles
1.
Wolstenhulme F, Bibby I, Cole M, Grixti L, McGregor N, Bradley P, et al.
BMJ Open
. 2024 Jun;
14(6):e079158.
PMID: 38866568
Introduction: Severe Graves' disease is a life-changing condition with poor outcomes from currently available treatments. It is caused by directly pathogenic thyroid-stimulating hormone receptor-stimulating antibodies (TRAb), which are secreted from...
2.
Grixti L, Lane L, Pearce S
Rev Endocr Metab Disord
. 2023 Dec;
25(1):203-214.
PMID: 38108994
Graves' disease (GD) is the commonest cause of hyperthyroidism and has a strong female preponderance. Everyday clinical practice suggests strong aggregation within families and twin studies demonstrate that genetic factors...
3.
Ahluwalia R, Baldeweg S, Boelaert K, Chatterjee K, Dayan C, Okosieme O, et al.
Clin Endocrinol (Oxf)
. 2023 Jun;
99(2):206-216.
PMID: 37272400
Persistent symptoms in patients treated for hypothyroidism are common. Despite more than 20 years of debate, the use of liothyronine for this indication remains controversial, as numerous randomised trials have...
4.
Perros P, Zarkovic M, Pearce S, Razvi S, Kolli H, Dickinson A
Am J Ophthalmol
. 2023 Apr;
252:94-100.
PMID: 37028695
Purpose: Thyroid eye disease (TED) can be difficult to manage. The range of available treatments is expanding rapidly; however, cost is a concern and some patients do not respond. The...
5.
Howarth S, Giovanelli L, Napier C, Pearce S
Endocr Connect
. 2022 Nov;
12(1).
PMID: 36398876
Autoimmune Addison's disease (AAD) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. This destruction of steroid-producing cells has historically been thought of as an...
6.
Hegedus L, Bianco A, Jonklaas J, Pearce S, Weetman A, Perros P
Nat Rev Endocrinol
. 2022 Jan;
18(4):230-242.
PMID: 35042968
In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic L form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of hypothyroidism. The...
7.
Mooij C, Cheetham T, Verburg F, Eckstein A, Pearce S, Leger J, et al.
Eur Thyroid J
. 2022 Jan;
11(1).
PMID: 34981748
Hyperthyroidism caused by Graves' disease (GD) is a relatively rare disease in children. Treatment options are the same as in adults - antithyroid drugs (ATD), radioactive iodine (RAI) or thyroid...
8.
Pearce S, Wiersinga W
Eur Thyroid J
. 2021 Dec;
10(6):437-438.
PMID: 34956916
No abstract available.
9.
Razvi S, Arnott B, Teare D, Hiu S, OBrien N, Pearce S
Eur Thyroid J
. 2021 Aug;
10(4):330-338.
PMID: 34395305
Background: International societies have recommended that levothyroxine should not routinely be prescribed in older individuals for the management of mild subclinical hypothyroidism (SCH). However, it is unknown whether clinicians managing...
10.
Gan E, Jagger C, Yadegarfar M, Duncan R, Pearce S
Thyroid
. 2021 Jun;
31(8):1182-1191.
PMID: 34074153
Low serum thyrotropin (TSH) has been associated with an increased risk of cognitive impairment in observational studies of older individuals, but the mechanism underlying this is unclear. We investigated the...