Simon Duchesne
Overview
Explore the profile of Simon Duchesne including associated specialties, affiliations and a list of published articles.
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118
Citations
1669
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Recent Articles
1.
Smith E, Phillips N, Feldman H, Borrie M, Ganesh A, Henri-Bhargava A, et al.
J Prev Alzheimers Dis
. 2025 Feb;
12(3):100068.
PMID: 39893139
Lecanemab and donanemab are monoclonal antibody therapies that remove amyloid-beta from the brain. They are the first therapies that alter a fundamental mechanism, amyloid-beta deposition, in Alzheimer disease (AD). To...
2.
Lamontagne-Caron R, Duchesne S
Front Dement
. 2024 Nov;
3:1408782.
PMID: 39588202
Introduction: Deregulation of the cerebrovascular system has been linked to neurodegeneration, part of a putative causal pathway into etiologies such as Alzheimer's disease (AD). In medical imaging, time-of-flight magnetic resonance...
3.
Duchesne S, Collins D, Barlow L, Bartha R, Black S, Chertkow H, et al.
Can J Neurol Sci
. 2024 Nov;
1-9.
PMID: 39494933
Background: Disease-modifying therapies (DMTs) for Alzheimer's disease (AD) are emerging following successful clinical trials of therapies targeting amyloid beta (Aβ) protofibrils or plaques. Determining patient eligibility and monitoring treatment efficacy...
4.
Guan D, Rehman T, Nathan S, Durrani R, Potvin O, Duchesne S, et al.
Hum Brain Mapp
. 2024 Sep;
45(13):e70016.
PMID: 39254167
Neuropsychiatric symptoms (NPS) are risk factors for Alzheimer's disease (AD) but can also manifest secondary to AD pathology. Mild behavioral impairment (MBI) refers to later-life emergent and persistent NPS that...
5.
Gourdeau D, Duchesne S, Archambault L
Biomed Phys Eng Express
. 2024 Aug;
10(6).
PMID: 39178886
Some pathologies such as cancer and dementia require multiple imaging modalities to fully diagnose and assess the extent of the disease. Magnetic resonance imaging offers this kind of polyvalence, but...
6.
Motaghi M, Potvin O, Duchesne S
Front Dement
. 2024 Jul;
3:1418037.
PMID: 39081608
Introduction: Type 2 diabetes (T2D) has been linked to cognitive impairment and dementia, but its impact on brain cortical structures in individuals prior to or without cognitive impairment remains unclear....
7.
Beheshti I, Potvin O, Dadar M, Duchesne S
Front Dement
. 2024 Jul;
3:1380015.
PMID: 39081605
Introduction: White matter hyperintensities (WMHs) and cerebral microbleeds are widespread among aging population and linked with cognitive deficits in mild cognitive impairment (MCI), vascular MCI (V-MCI), and Alzheimer's disease without...
8.
Duchesne S, Rousseau L, Belzile-Marsolais F, Welch L, Cournoyer B, Arseneau M, et al.
J Alzheimers Dis
. 2024 May;
99(3):843-856.
PMID: 38788067
Background: There is a common agreement that Alzheimers disease (AD) is inherently complex; otherwise, a general disagreement remains on its etiological underpinning, with numerous alternative hypotheses having been proposed. Objective:...
9.
Chamberland E, Moravveji S, Doyon N, Duchesne S
Front Neuroinform
. 2024 Apr;
18:1348113.
PMID: 38586183
Introduction: Mathematical models play a crucial role in investigating complex biological systems, enabling a comprehensive understanding of interactions among various components and facilitating testing of intervention strategies. Alzheimer's disease (AD)...
10.
Moravveji S, Doyon N, Mashreghi J, Duchesne S
Front Neuroinform
. 2024 Mar;
18:1281656.
PMID: 38550514
Alzheimer's disease is a complex, multi-factorial, and multi-parametric neurodegenerative etiology. Mathematical models can help understand such a complex problem by providing a way to explore and conceptualize principles, merging biological...