Simon Beggs
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Explore the profile of Simon Beggs including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
4200
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Recent Articles
1.
Forsyth P, Young S, Hughes K, James R, Oxley C, Kelly R, et al.
Open Heart
. 2024 Jan;
11(1).
PMID: 38242561
Objective: Heart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old....
2.
Xu Y, Koch S, Chamessian A, He Q, Sundukova M, Heppenstall P, et al.
J Neurosci
. 2023 Nov;
44(2).
PMID: 37989592
Sensory systems are shaped in postnatal life by the refinement of synaptic connectivity. In the dorsal horn of the spinal cord, somatosensory circuits undergo postnatal activity-dependent reorganization, including the refinement...
3.
Xu Y, Moulding D, Jin W, Beggs S
Brain Behav Immun
. 2023 Apr;
111:127-137.
PMID: 37037363
Peripheral injury during the early postnatal period alters the somatosensory system, leading to behavioural hyperalgesia upon re-injury in adulthood. Spinal microglia have been implicated as the cellular mediators of this...
4.
Tu Y, Muley M, Beggs S, Salter M
Pain
. 2022 Apr;
163(11):e1129-e1144.
PMID: 35384869
The dominant view in the field of pain is that peripheral neuropathic pain is driven by microglia in the somatosensory processing region of the spinal dorsal horn. Here, to the...
5.
Moriarty O, Tu Y, Sengar A, Salter M, Beggs S, Walker S
J Neurosci
. 2019 Feb;
39(16):3081-3093.
PMID: 30796159
Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this persistent effect, and microglial inhibition at the time of...
6.
Mapplebeck J, Dalgarno R, Tu Y, Moriarty O, Beggs S, Kwok C, et al.
Pain
. 2018 Jun;
159(9):1752-1763.
PMID: 29927790
Microglia-neuron signalling in the spinal cord is a key mediator of mechanical allodynia caused by peripheral nerve injury. We recently reported sex differences in microglia in pain signalling in mice:...
7.
8.
Mapplebeck J, Beggs S, Salter M
Mol Brain
. 2017 Mar;
10(1):9.
PMID: 28270169
Microglia are dynamic immune cells with diverse roles in maintaining homeostasis of the central nervous system. Dysregulation of microglia has been critically implicated in the genesis of neuropathic pain. Peripheral...
9.
Hildebrand M, Xu J, Dedek A, Li Y, Sengar A, Beggs S, et al.
Cell Rep
. 2016 Dec;
17(10):2753-2765.
PMID: 27926876
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition. Pain hypersensitivity also depends on N-methyl-D-aspartate receptors (NMDARs)...
10.
Beggs S, Salter M
Cell
. 2016 May;
165(5):1294-1294.e1.
PMID: 27203115
The development and maintenance of the central nervous system is dependent upon regulated, homeostatic actions of microglia, which sculpt and refine neuronal circuitry. By contrast, dysregulation of microglia contributes to...