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Sigrid Leyendecker

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Recent Articles
1.
Coppers B, Heinrich S, Tascilar K, Phutane U, Kleyer A, Simon D, et al.
Sci Rep . 2025 Feb; 15(1):6018. PMID: 39972020
Quantifying physical impairment in rheumatoid arthritis (RA) is important to determine disease burden and disability. Therefore, we aimed to define hand function impairments in RA patients using an opto-electronic measurement...
2.
Wechsler I, Wolf A, Shanbhag J, Leyendecker S, Eskofier B, Koelewijn A, et al.
Front Bioeng Biotechnol . 2024 Jun; 12:1386874. PMID: 38919383
Musculoskeletal simulations can be used to estimate biomechanical variables like muscle forces and joint torques from non-invasive experimental data using inverse and forward methods. Inverse kinematics followed by inverse dynamics...
3.
Chen X, Leyendecker S
Mol Inform . 2024 Jun; 43(6):e202300250. PMID: 38850084
Protein kinases are crucial cellular enzymes that facilitate the transfer of phosphates from adenosine triphosphate (ATP) to their substrates, thereby regulating numerous cellular activities. Dysfunctional kinase activity often leads to...
4.
Nitschke M, Dorschky E, Leyendecker S, Eskofier B, Koelewijn A
Front Bioeng Biotechnol . 2024 Apr; 12:1285845. PMID: 38628437
Portable measurement systems using inertial sensors enable motion capture outside the lab, facilitating longitudinal and large-scale studies in natural environments. However, estimating 3D kinematics and kinetics from inertial data for...
5.
Shanbhag J, Wolf A, Wechsler I, Fleischmann S, Winkler J, Leyendecker S, et al.
J Neuroeng Rehabil . 2023 Aug; 20(1):111. PMID: 37605197
Understanding of the human body's internal processes to maintain balance is fundamental to simulate postural control behaviour. The body uses multiple sensory systems' information to obtain a reliable estimate about...
6.
Martonova D, Holz D, Duong M, Leyendecker S
J Biomech . 2023 Jul; 157:111691. PMID: 37441914
In modelling and simulation of cardiac mechanics, tetrahedral meshes are often used due to the easy availability of efficient meshing algorithms. This is beneficial in particular when complex geometries such...
7.
Chen X, Leyendecker S, van den Bedem H
Proteins . 2023 Jul; 91(11):1496-1509. PMID: 37408369
The Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. COVID-19 continues to cause millions of deaths globally in part due to immune-evading mutations....
8.
Holz D, Martonova D, Schaller E, Duong M, Alkassar M, Weyand M, et al.
J Biomech . 2023 Jun; 156:111643. PMID: 37321157
It is well known that the orthotropic tissue structure decisively influences the mechanical and electrical properties of the heart. Numerous approaches to compute the orthotropic tissue structure in computational heart...
9.
Martonova D, Lavaill M, Forwood M, Robling A, Cooper D, Leyendecker S, et al.
PLoS One . 2023 Mar; 18(3):e0283544. PMID: 36996072
Temporal aspects of ligand specificity have been shown to play a significant role in the case of pulsatile hormone secretion, as exemplified by parathyroid hormone (PTH) binding to its receptor...
10.
Huang D, Leyendecker S
Soft Robot . 2023 Mar; 10(5):897-911. PMID: 36976775
In this work, a simulation model for the optimal control of dielectric elastomer actuated flexible multibody dynamics systems is presented. The dielectric elastomer actuator (DEA) behaves like a flexible artificial...