Sigrid A Otto
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Explore the profile of Sigrid A Otto including associated specialties, affiliations and a list of published articles.
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29
Citations
1197
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Recent Articles
1.
Nuhn M, Bosman K, Huisman T, Staring W, Gharu L, De Jong D, et al.
AIDS
. 2025 Feb;
PMID: 39964317
Objectives: To investigate the short- and long-term dynamics of intact and defective proviral HIV DNA during ART. Design: We evaluated viral reservoir dynamics in a cohort of nine individuals with...
2.
Baliu-Pique M, Drylewicz J, Zheng X, Borkner L, Swain A, Otto S, et al.
J Immunol
. 2022 Jan;
208(4):799-806.
PMID: 35091435
The potential of memory T cells to provide protection against reinfection is beyond question. Yet, it remains debated whether long-term T cell memory is due to long-lived memory cells. There...
3.
van den Berg S, Derksen L, Drylewicz J, Nanlohy N, Beckers L, Lanfermeijer J, et al.
PLoS Pathog
. 2021 Dec;
17(12):e1010152.
PMID: 34914799
Cytomegalovirus (CMV) infection has a major impact on the T-cell pool, which is thought to be associated with ageing of the immune system. The effect on the T-cell pool has...
4.
Baliu-Pique M, van Hoeven V, Drylewicz J, van der Wagen L, Janssen A, Otto S, et al.
Elife
. 2021 Feb;
10.
PMID: 33538246
Lymphocyte numbers need to be quite tightly regulated. It is generally assumed that lymphocyte production and lifespan increase homeostatically when lymphocyte numbers are low and, vice versa, return to normal...
5.
Baliu-Pique M, Otto S, Borghans J, Tesselaar K
Immunol Lett
. 2019 Apr;
210:29-32.
PMID: 31004681
The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained...
6.
Krikke M, Tesselaar K, van den Berk G, Otto S, Freriks L, Van Lelyveld S, et al.
HIV Clin Trials
. 2018 May;
19(2):75-83.
PMID: 29770748
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has...
7.
Krikke M, Tesselaar K, Arends J, Drylewicz J, Otto S, Van Lelyveld S, et al.
Infect Dis Ther
. 2016 Jun;
5(3):389-404.
PMID: 27300170
Background: The increased risk of abacavir in cardiovascular disease (CVD) in HIV-infected patients is still being debated. Maraviroc, a CCR5 blocker, has been shown to decrease immune activation and monocyte...
8.
Drylewicz J, Vrisekoop N, Mugwagwa T, de Boer A, Otto S, Hazenberg M, et al.
PLoS One
. 2016 Mar;
11(3):e0152513.
PMID: 27010200
Naive T cells in untreated HIV-1 infected individuals have a reduced T-cell receptor excision circle (TREC) content. Previous mathematical models have suggested that this is due to increased naive T-cell...
9.
Vrisekoop N, Drylewicz J, van Gent R, Mugwagwa T, Van Lelyveld S, Veel E, et al.
AIDS
. 2015 Jul;
29(16):2071-80.
PMID: 26213901
Background: In HIV infection, the homeostasis of CD4 and CD8 T cells is dramatically disturbed, and several studies have pointed out that T-cell turnover rates are increased. To understand how...
10.
Van Lelyveld S, Drylewicz J, Krikke M, Veel E, Otto S, Richter C, et al.
PLoS One
. 2015 Jul;
10(7):e0132430.
PMID: 26208341
Objective: The immunomodulatory effects of the CCR5-antagonist maraviroc might be beneficial in patients with a suboptimal immunological response, but results of different cART (combination antiretroviral therapy) intensification studies are conflicting....