Siew-Kim Khoo
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Explore the profile of Siew-Kim Khoo including associated specialties, affiliations and a list of published articles.
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46
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440
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Recent Articles
1.
Coenen I, de Jong E, Jones A, Khoo S, Foo S, Howland S, et al.
J Allergy Clin Immunol
. 2023 Dec;
153(4):1083-1094.
PMID: 38110059
Background: Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity as...
2.
Jones A, Leffler J, Laing I, Bizzintino J, Khoo S, LeSouef P, et al.
Respir Res
. 2023 Jul;
24(1):184.
PMID: 37438758
Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the...
3.
Ariff A, Song Y, Aguilar R, Nhabomba A, Manaca M, Khoo S, et al.
Malar J
. 2023 Jun;
22(1):177.
PMID: 37287037
Background: Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. Methods: One hundred...
4.
Coleman L, Khoo S, Franks K, Prastanti F, Le Souef P, Karpievitch Y, et al.
J Pers Med
. 2021 Dec;
11(12).
PMID: 34945765
Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during...
5.
Oo S, Khoo S, Cox D, Chidlow G, Franks K, Prastanti F, et al.
Pediatr Infect Dis J
. 2021 Jul;
40(10):873-879.
PMID: 34321447
Background: Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species...
6.
Annamalay A, Abbott S, Khoo S, Hibbert J, Bizzintino J, Zhang G, et al.
J Med Virol
. 2020 Dec;
93(6):3647-3655.
PMID: 33314189
Altered host immune responses are considered to play a key role in the pathogenesis of acute lower respiratory infections (ALRI). The existing literature on cytokine responses in ALRI is largely...
7.
Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
Cuthbertson L, Oo S, Cox M, Khoo S, Cox D, Chidlow G, et al.
PLoS One
. 2019 Oct;
14(10):e0223990.
PMID: 31622414
Acute viral wheeze in children is a major cause of hospitalisation and a major risk factor for the development of asthma. However, the role of the respiratory tract microbiome in...
8.
Khoo S, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, et al.
J Immunol
. 2019 Feb;
202(6):1845-1858.
PMID: 30745463
Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying asthma exacerbation phenotypes in children. Cluster analysis unveiled distinct IRF7...
9.
Song Y, Aguilar R, Guo J, Manaca M, Nhabomba A, Berthoud T, et al.
Sci Rep
. 2018 Jul;
8(1):10860.
PMID: 30022038
Using a well-designed longitudinal cohort, we aimed to identify cytokines that were protective against malaria and to explore how they were influenced by genetic and immunological factors. 349 Mozambican pregnant...
10.
Cox D, Khoo S, Zhang G, Lindsay K, Keil A, Knight G, et al.
Eur Respir J
. 2018 Jul;
52(2).
PMID: 29976655
No abstract available.