Sidhartha Mahali
Overview
Explore the profile of Sidhartha Mahali including associated specialties, affiliations and a list of published articles.
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4
Citations
84
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Recent Articles
1.
Filipello F, You S, Mirfakhar F, Mahali S, Bollman B, Acquarone M, et al.
Acta Neuropathol
. 2023 Apr;
145(6):749-772.
PMID: 37115208
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia,...
2.
Minaya M, Mahali S, Iyer A, Eteleeb A, Martinez R, Huang G, et al.
Front Mol Biosci
. 2023 Feb;
10:1051494.
PMID: 36845551
More than 50 mutations in the gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree...
3.
Mahali S, Martinez R, King M, Verbeck A, Harari O, Benitez B, et al.
Transl Psychiatry
. 2022 Dec;
12(1):508.
PMID: 36494352
Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of protein, which can be toxic to cells and tissue. In...
4.
Bowles K, Silva M, Whitney K, Bertucci T, Berlind J, Lai J, et al.
Cell
. 2021 Jul;
184(17):4547-4563.e17.
PMID: 34314701
Frontotemporal dementia (FTD) because of MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used human induced pluripotent stem cell (iPSC)-derived cerebral organoids...