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Siddhika Pareek

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Articles 20
Citations 168
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Recent Articles
1.
Garg P, Singhal G, Pareek S, Kulkarni P, Horne D, Nath A, et al.
Biochim Biophys Acta Rev Cancer . 2024 Dec; 1880(1):189233. PMID: 39638158
Gene editing techniques have emerged as powerful tools in biomedical research, offering precise manipulation of genetic material with the potential to revolutionize cancer treatment strategies. This review provides a comprehensive...
2.
Garg P, Pareek S, Kulkarni P, Horne D, Salgia R, Singhal S
Biochem Pharmacol . 2024 Nov; 231:116646. PMID: 39577704
Transforming Growth Factor-beta (TGF-β) is a multifunctional cytokine that exerts its biological effects through a complex process of activation and signaling. Initially synthesized in an inactive form bound to latency-associated...
3.
Garg P, Pareek S, Kulkarni P, Horne D, Salgia R, Singhal S
J Clin Med . 2024 Nov; 13(21). PMID: 39518676
Next-generation immunotherapies have revolutionized cancer treatment, offering hope for patients with hard-to-treat tumors. This review focuses on the clinical applications and advancements of key immune-based therapies, including immune checkpoint inhibitors,...
4.
Garg P, Ramisetty S, Subbalakshmi A, Krishna B, Pareek S, Mohanty A, et al.
Biochem Pharmacol . 2024 Aug; 229:116498. PMID: 39159874
Gynecological cancers, including ovarian, cervical, endometrial, and vulvar cancers, present significant challenges in diagnosis and treatment globally. The tumor microenvironment (TME) plays a pivotal role in cancer progression and therapy...
5.
Subbalakshmi A, Ramisetty S, Mohanty A, Pareek S, Do D, Shrestha S, et al.
J Clin Med . 2024 Aug; 13(15). PMID: 39124569
Epithelial-to-mesenchymal transition (EMT) is a major axis of phenotypic plasticity not only in diseased conditions such as cancer metastasis and fibrosis but also during normal development and wound healing. Yet-another...
6.
Garg P, Pareek S, Kulkarni P, Salgia R, Singhal S
J Clin Med . 2024 Jun; 13(12). PMID: 38929995
Nanoengineering has emerged as a progressive method in cancer treatment, offering precise and targeted delivery of therapeutic agents while concurrently reducing overall toxicity. This scholarly article delves into the innovative...
7.
Ramisetty S, Subbalakshmi A, Pareek S, Mirzapoiazova T, Do D, Prabhakar D, et al.
J Clin Med . 2024 Jun; 13(11). PMID: 38893049
Cancer cells, like all other organisms, are adept at switching their phenotype to adjust to the changes in their environment. Thus, phenotypic plasticity is a quantitative trait that confers a...
8.
Ling A, Zhang W, Lee A, Xia Y, Su M, Gruener R, et al.
J Cancer Sci Clin Ther . 2024 Mar; 7(4):249-252. PMID: 38435702
High-throughput drug screens are a powerful tool for cancer drug development. However, the results of such screens are often made available only as raw data, which is intractable for researchers...
9.
Xia Y, Ling A, Zhang W, Lee A, Su M, Gruener R, et al.
J Cancer Sci Clin Ther . 2024 Feb; 7(4):253-258. PMID: 38344217
We recently reported a computational method (IDACombo) designed to predict the efficacy of cancer drug combinations using monotherapy response data and the assumptions of independent drug action. Given the strong...
10.
Ling A, Zhang W, Lee A, Xia Y, Su M, Gruener R, et al.
bioRxiv . 2023 Sep; PMID: 37745579
High-throughput drug screens are a powerful tool for cancer drug development. However, the results of such screens are often made available only as raw data, which is intractable for researchers...