Shuanglong Yi
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Explore the profile of Shuanglong Yi including associated specialties, affiliations and a list of published articles.
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6
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20
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Recent Articles
1.
Zhang S, Wang L, Yi S, Tsai Y, Cheng Y, Lin Y, et al.
Autophagy
. 2025 Jan;
1-20.
PMID: 39878136
Glia contribute to the neuropathology of Parkinson disease (PD), but how they react opposingly to be beneficial or detrimental under pathological conditions, like promoting or eliminating SNCA/α-syn (synuclein alpha) inclusions,...
2.
Wang L, Yi S, Zhang S, Tsai Y, Cheng Y, Lin Y, et al.
ASN Neuro
. 2025 Jan;
17(1):2443442.
PMID: 39807990
We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present...
3.
Yi S, Wang L, Ho M, Zhang S
Neural Regen Res
. 2023 Oct;
19(5):1150-1155.
PMID: 37862221
Parkinson's disease is a progressive neurodegenerative disease characterized by motor deficits, dopaminergic neuron loss, and brain accumulation of α-synuclein aggregates called Lewy bodies. Dysfunction in protein degradation pathways, such as...
4.
Wang L, Zhang S, Yi S, Ho M
Autophagy
. 2023 Aug;
20(1):207-209.
PMID: 37615623
Macroautophagy/autophagy is the major degradation pathway in neurons for eliminating damaged proteins and organelles in Parkinson disease (PD). Like neurons, glial cells are important contributors to PD, yet how autophagy...
5.
Zhang S, Yi S, Wang L, Li S, Wang H, Song L, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2301002120.
PMID: 37428930
Autophagy is a major means for the elimination of protein inclusions in neurons in neurodegenerative diseases such as Parkinson's disease (PD). Yet, the mechanism of autophagy in the other brain...
6.
Yi S, Wang L, Wang H, Ho M, Zhang S
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499080
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such...
7.
A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival
Wang L, Wang H, Yi S, Zhang S, Ho M
Traffic
. 2022 Sep;
23(10):506-520.
PMID: 36053864
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson's disease. A plethora of evidence has indicated a role for LRRK2 in endolysosomal...
8.
Yang M, Wang H, Chen C, Zhang S, Wang M, Senapati B, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(23).
PMID: 34078666
Intrinsic mechanisms such as temporal series of transcription factors orchestrate neurogenesis from a limited number of neural progenitors in the brain. Extrinsic regulations, however, remain largely unexplored. Here we describe...