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Shu-Yu Liao

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Articles 6
Citations 78
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Recent Articles
1.
Vandeveer G, Arduini R, Baker D, Barry K, Bohnert T, Bowden-Verhoek J, et al.
Bioorg Med Chem Lett . 2022 Dec; 80:129108. PMID: 36538993
For the past two decades, BTK a tyrosine kinase and member of the Tec family has been a drug target of significant interest due to its potential to selectively treat...
2.
Gelenter M, Smith K, Liao S, Mandala V, Dregni A, Lamm M, et al.
Nat Struct Mol Biol . 2019 Jun; 26(7):592-598. PMID: 31235909
Glucagon and insulin maintain blood glucose homeostasis and are used to treat hypoglycemia and hyperglycemia, respectively, in patients with diabetes. Whereas insulin is stable for weeks in its solution formulation,...
3.
Mandala V, Liao S, Gelenter M, Hong M
Sci Rep . 2019 Mar; 9(1):3725. PMID: 30842530
Influenza A and B viruses cause seasonal flu epidemics. The M2 protein of influenza B (BM2) is a membrane-embedded tetrameric proton channel that is essential for the viral lifecycle. BM2...
4.
Gelenter M, Wang T, Liao S, ONeill H, Hong M
J Biomol NMR . 2017 Jul; 68(4):257-270. PMID: 28674916
Site-specific determination of molecular motion and water accessibility by indirect detection of H NMR spectra has advantages over dipolar-coupling based techniques due to the large quadrupolar couplings and the ensuing...
5.
Mandala V, Liao S, Kwon B, Hong M
J Mol Biol . 2017 May; 429(14):2192-2210. PMID: 28535993
The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH while W41 ensures proton conduction...
6.
Yao H, Lee M, Liao S, Hong M
Biochemistry . 2016 Oct; 55(49):6787-6800. PMID: 27766858
The fusion peptide (FP) and transmembrane domain (TMD) of viral fusion proteins play important roles during virus-cell membrane fusion, by inducing membrane curvature and transient dehydration. The structure of the...