Shrividhya Srinivasan
Overview
Explore the profile of Shrividhya Srinivasan including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
387
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Recent Articles
1.
Yen I, Shanahan F, Lee J, Hong Y, Shin S, Moore A, et al.
Nature
. 2021 May;
594(7863):418-423.
PMID: 33953400
Although RAF monomer inhibitors (type I.5, BRAF(V600)) are clinically approved for the treatment of BRAF-mutant melanoma, they are ineffective in non-BRAF mutant cells. Belvarafenib is a potent and selective RAF...
2.
Wagle M, Castillo J, Srinivasan S, Holcomb T, Yuen K, Kadel E, et al.
Cancer Immunol Res
. 2020 Apr;
8(7):844-850.
PMID: 32321776
Prostate cancer is the second leading cause of cancer-related death in men. Despite having a relatively lower tumor mutational burden than most tumor types, multiple gene fusions such as have...
3.
Angulo B, Srinivasan S, Bolival B, Olivares G, Spence A, Fuller M
PLoS Genet
. 2019 Jun;
15(6):e1008187.
PMID: 31226128
Active adult stem cells maintain a bipotential state with progeny able to either self-renew or initiate differentiation depending on extrinsic signals from the surrounding microenvironment. However, the intrinsic gene regulatory...
4.
Castillo J, Wu E, Lowe C, Srinivasan S, McCord R, Wagle M, et al.
Cancer Res
. 2019 Jun;
79(15):3916-3927.
PMID: 31182547
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms...
5.
Wagle M, Kirouac D, Klijn C, Liu B, Mahajan S, Junttila M, et al.
NPJ Precis Oncol
. 2018 Jun;
2(1):7.
PMID: 29872725
- and -mutant tumors are often dependent on MAPK signaling for proliferation and survival and thus sensitive to MAPK pathway inhibitors. However, clinical studies have shown that MEK inhibitors are...
6.
Kim J, Lu C, Srinivasan S, Awe S, Brehm A, Fuller M
Science
. 2017 May;
356(6339):717-721.
PMID: 28522526
To selectively express cell type-specific transcripts during development, it is critical to maintain genes required for other lineages in a silent state. Here, we show in the male germline stem...
7.
Morillo Prado J, Srinivasan S, Fuller M
PLoS Genet
. 2013 Nov;
9(11):e1003903.
PMID: 24244183
Many tissues are sustained by adult stem cells, which replace lost cells by differentiation and maintain their own population through self-renewal. The mechanisms through which adult stem cells maintain their...
8.
Srinivasan S, Mahowald A, Fuller M
Development
. 2012 Mar;
139(8):1381-90.
PMID: 22378638
The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane...
9.
Srinivasan S, Dorighi K, Tamkun J
PLoS Genet
. 2008 Oct;
4(10):e1000217.
PMID: 18846226
Polycomb and trithorax group proteins regulate cellular pluripotency and differentiation by maintaining hereditable states of transcription. Many Polycomb and trithorax group proteins have been implicated in the covalent modification or...
10.
Srinivasan S, Armstrong J, Deuring R, Dahlsveen I, McNeill H, Tamkun J
Development
. 2005 Feb;
132(7):1623-35.
PMID: 15728673
The Drosophila trithorax group gene kismet (kis) was identified in a screen for extragenic suppressors of Polycomb (Pc) and subsequently shown to play important roles in both segmentation and the...