Shmuel Gleizer
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Explore the profile of Shmuel Gleizer including associated specialties, affiliations and a list of published articles.
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10
Citations
490
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Recent Articles
1.
Ben Nissan R, Milshtein E, Pahl V, de Pins B, Jona G, Levi D, et al.
Elife
. 2024 Feb;
12.
PMID: 38381041
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that...
2.
Sender R, Bar-On Y, Gleizer S, Bernshtein B, Flamholz A, Phillips R, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34083352
Quantitatively describing the time course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for understanding the current global pandemic and possible ways...
3.
Sender R, Bar-On Y, Gleizer S, Bernsthein B, Flamholz A, Phillips R, et al.
medRxiv
. 2020 Nov;
PMID: 33236021
Quantitatively describing the time course of the SARS-CoV-2 infection within an infected individual is important for understanding the current global pandemic and possible ways to combat it. Here we integrate...
4.
Flamholz A, Dugan E, Blikstad C, Gleizer S, Ben-Nissan R, Amram S, et al.
Elife
. 2020 Oct;
9.
PMID: 33084575
Many photosynthetic organisms employ a CO concentrating mechanism (CCM) to increase the rate of CO fixation via the Calvin cycle. CCMs catalyze ≈50% of global photosynthesis, yet it remains unclear...
5.
Gleizer S, Ben-Nissan R, Bar-On Y, Antonovsky N, Noor E, Zohar Y, et al.
Cell
. 2019 Nov;
179(6):1255-1263.e12.
PMID: 31778652
The living world is largely divided into autotrophs that convert CO into biomass and heterotrophs that consume organic compounds. In spite of widespread interest in renewable energy storage and more...
6.
Bachar A, Itzhaki E, Gleizer S, Shamshoom M, Milo R, Antonovsky N
Nucleic Acids Res
. 2019 Nov;
48(2):761-769.
PMID: 31777935
Identifying the molecular mechanisms that give rise to genetic variation is essential for the understanding of evolutionary processes. Previously, we have used adaptive laboratory evolution to enable biomass synthesis from...
7.
Herz E, Antonovsky N, Bar-On Y, Davidi D, Gleizer S, Prywes N, et al.
Nat Commun
. 2017 Nov;
8(1):1705.
PMID: 29167457
Understanding the evolution of a new metabolic capability in full mechanistic detail is challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations accumulated during the evolutionary trajectory. We...
8.
Antonovsky N, Gleizer S, Milo R
Curr Opin Biotechnol
. 2017 Jul;
47:83-91.
PMID: 28715702
Carbon fixation is the gateway of inorganic carbon into the biosphere. Our ability to engineer carbon fixation pathways in living organisms is expected to play a crucial role in the...
9.
Antonovsky N, Gleizer S, Noor E, Zohar Y, Herz E, Barenholz U, et al.
Cell
. 2016 Jun;
166(1):115-25.
PMID: 27345370
Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive...
10.
Zelcbuch L, Lindner S, Zegman Y, Vainberg Slutskin I, Antonovsky N, Gleizer S, et al.
Biochemistry
. 2016 Apr;
55(17):2423-6.
PMID: 27093333
Pyruvate formate-lyase (PFL) is a ubiquitous enzyme that supports increased ATP yield during sugar fermentation. While the PFL reaction is known to be reversible in vitro, the ability of PFL...