Shiyuan Hong
Overview
Explore the profile of Shiyuan Hong including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
432
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0
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Recent Articles
1.
Luo Y, Niu M, Liu Y, Zhang M, Deng Y, Mu D, et al.
Front Pharmacol
. 2024 Aug;
15:1450875.
PMID: 39156107
Cervical cancer (CC) stands as a significant health threat to women globally, with high-risk human papillomaviruses as major etiologic agents. The DNA damage repair (DDR) protein topoisomerase I (TOP1) has...
2.
Liu Y, Niu M, Luo Y, Pan M, Hong S
J Med Virol
. 2024 Jul;
96(8):e29815.
PMID: 39073137
Human papillomaviruses (HPVs) are non-enveloped double-stranded DNA viruses. When HPV infection persists, infected tissues can develop many HPV-related diseases such as cervical cancer and head and neck squamous cell carcinoma....
3.
Cen Y, Fang Y, Ren Y, Hong S, Lu W, Xu J
Cell Death Dis
. 2022 Apr;
13(4):342.
PMID: 35418185
High grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer and HGSOC patients often appear with metastasis, leading to the poor prognosis. Up to date, the...
4.
Xu J, Shen Y, Wang C, Tang S, Hong S, Lu W, et al.
Cell Death Discov
. 2021 Sep;
7(1):259.
PMID: 34552062
The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors show survival benefits in ovarian cancer patients with BRCA1/2 mutation or homologous recombination (HR) deficiency, but only limited efficacy in HR-proficient ones. Another drug,...
5.
Kaminski P, Hong S, Kono T, Hoover P, Laimins L
mBio
. 2021 Feb;
12(1).
PMID: 33563836
Topoisomerases regulate higher-order chromatin structures through the transient breaking and religating of one or both strands of the phosphodiester backbone of duplex DNA. TOP2β is a type II topoisomerase that...
6.
Hong S, Li Y, Kaminski P, Andrade J, Laimins L
mBio
. 2020 Aug;
11(4).
PMID: 32788179
High-risk human papillomaviruses (HPVs) constitutively activate the ataxia telangiectasia and Rad3-related (ATR) DNA damage response pathway, and this is required for viral replication. In fibroblasts, activated ATR regulates transcription of...
7.
Luo Y, Hong S
Pathogens
. 2020 Jun;
9(6).
PMID: 32585979
Human papillomavirus (HPV) infection leads to a variety of benign lesions and malignant tumors such as cervical cancer and head and neck squamous cell carcinoma. Several HPV vaccines have been...
8.
Hong S, Xu J, Li Y, Andrade J, Hoover P, Kaminski P, et al.
Oncogene
. 2019 Jan;
38(17):3274-3287.
PMID: 30631149
High-risk human papillomaviruses (HPVs) constitutively activate ataxia telangiectasia mutated (ATM) and ataxia telangiectasia- and Rad3-related (ATR) DNA damage repair pathways for viral genome amplification. HPVs activate these pathways through the...
9.
Hong S, Cheng S, Songock W, Bodily J, Laimins L
J Virol
. 2017 Oct;
91(24).
PMID: 28978708
High-risk human papillomaviruses (HPVs) link their life cycle to epithelial differentiation and require activation of DNA damage pathways for efficient replication. HPVs modulate the expression of cellular transcription factors, as...
10.
Hong S, Laimins L
Virus Res
. 2016 Nov;
231:34-40.
PMID: 27826042
The innate immune response constitutes the first line of defense against infections by pathogens. Successful pathogens such as human papillomaviruses (HPVs) have evolved mechanisms that target several points in these...