Shirong Lai
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Explore the profile of Shirong Lai including associated specialties, affiliations and a list of published articles.
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9
Citations
168
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Recent Articles
1.
Lai S, Zhang L, Tu X, Ma X, Song Y, Cao K, et al.
Sci Adv
. 2024 Mar;
10(12):eadk9484.
PMID: 38507477
Epileptogenesis, arising from alterations in synaptic strength, shares mechanistic and phenotypic parallels with memory formation. However, direct evidence supporting the existence of seizure memory remains scarce. Leveraging a conditioned seizure...
2.
Wang M, Song Z, Lai S, Tang F, Dou L, Yang F
Front Microbiol
. 2024 Feb;
15:1292004.
PMID: 38357350
Depression is one of the most prevalent mental disorders today. Over the past decade, there has been considerable attention given to the field of gut microbiota associated with depression. A...
3.
Ke M, Yu Y, Zhao C, Lai S, Su Q, Yuan W, et al.
Cell Discov
. 2021 Sep;
7(1):77.
PMID: 34465718
No abstract available.
4.
Zhang J, Chen X, Eaton M, Wu J, Ma Z, Lai S, et al.
Cell Rep
. 2021 Aug;
36(5):109495.
PMID: 34348148
Scn2a encodes the voltage-gated sodium channel Na1.2, a main mediator of neuronal action potential firing. The current paradigm suggests that Na1.2 gain-of-function variants enhance neuronal excitability, resulting in epilepsy, whereas...
5.
Li X, Song G, Dou L, Yan S, Zhang M, Yuan W, et al.
Nanoscale
. 2021 Jun;
13(27):11827-11835.
PMID: 34152351
Hairpin structures play an essential role in DNA replication, transcription, and recombination. Single-molecule studies enable the real-time measurement and observation of the energetics and dynamics of hairpin structures, including folding...
6.
Eaton M, Zhang J, Ma Z, Park A, Lietzke E, Romero C, et al.
Genes Brain Behav
. 2020 Dec;
20(4):e12725.
PMID: 33369088
Large-scale genetic studies revealed SCN2A as one of the most frequently mutated genes in patients with neurodevelopmental disorders. SCN2A encodes for the voltage-gated sodium channel isoform 1.2 (Na 1.2) expressed...
7.
Liu Y, Li M, Fan M, Song Y, Yu H, Zhi X, et al.
Biol Psychiatry
. 2019 Jan;
85(8):635-649.
PMID: 30665597
Background: Major depressive disorder is a prevalent and life-threatening illness in modern society. The susceptibility to major depressive disorder is profoundly influenced by environmental factors, such as stressful lifestyle or...
8.
Xiao K, Sun Z, Jin X, Ma W, Song Y, Lai S, et al.
J Physiol
. 2018 Jul;
596(19):4729-4752.
PMID: 30016551
Key Points: ERG3 channels have a high expression level in the central nervous system. Knockdown of ERG3 channels enhances neuronal intrinsic excitability (caused by decreased fast afterhyperpolarization, shortened delay time...
9.
Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, et al.
Nat Commun
. 2017 Aug;
8(1):355.
PMID: 28842554
Impairment of intrinsic plasticity is involved in a range of neurological disorders such as epilepsy. However, how intrinsic excitability is regulated is still not fully understood. Here we report that...