Shirley L Markant
Overview
Explore the profile of Shirley L Markant including associated specialties, affiliations and a list of published articles.
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7
Citations
1117
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Recent Articles
1.
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Kool M, Jones D, Jager N, Northcott P, Pugh T, Hovestadt V, et al.
Cancer Cell
. 2014 Mar;
25(3):393-405.
PMID: 24651015
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH...
2.
Markant S, Esparza L, Sun J, Barton K, McCoig L, Grant G, et al.
Cancer Res
. 2013 Sep;
73(20):6310-22.
PMID: 24067506
Medulloblastoma is the most common malignant brain tumor in children. Although aggressive surgery, radiation, and chemotherapy have improved outcomes, survivors suffer severe long-term side effects, and many patients still succumb...
3.
Pei Y, Brun S, Markant S, Lento W, Gibson P, Taketo M, et al.
Development
. 2012 Mar;
139(10):1724-33.
PMID: 22461560
The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT pathway mutations are associated with medulloblastoma, the most common...
4.
Lau J, Schmidt C, Markant S, Taylor M, Wechsler-Reya R, Weiss W
Childs Nerv Syst
. 2012 Feb;
28(4):521-32.
PMID: 22315164
Introduction: Medulloblastoma, the largest group of embryonal brain tumors, has historically been classified into five variants based on histopathology. More recently, epigenetic and transcriptional analyses of primary tumors have subclassified...
5.
Read T, Fogarty M, Markant S, McLendon R, Wei Z, Ellison D, et al.
Cancer Cell
. 2009 Feb;
15(2):135-47.
PMID: 19185848
The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been...
6.
Yang Z, Ellis T, Markant S, Read T, Kessler J, Bourboulas M, et al.
Cancer Cell
. 2008 Aug;
14(2):135-45.
PMID: 18691548
Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in...
7.
Qiu X, Markant S, Yuan J, Goldberg A
EMBO J
. 2004 Feb;
23(4):800-10.
PMID: 14765125
Degradation of certain inhibitor of apoptosis proteins (IAPs) appears to be critical in the initiation of apoptosis, but the factors that regulate their degradation in mammalian cells are unknown. Nrdp1/FLRF...