Shirley A Williams
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Explore the profile of Shirley A Williams including associated specialties, affiliations and a list of published articles.
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10
Citations
184
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Recent Articles
1.
Buzby J, Williams S, Nugent D
Genes (Basel)
. 2022 Dec;
13(12).
PMID: 36553570
Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder where an oncogenic germline mutation is inherited by offspring of a carrier parent. p53 is a key tumor suppressor regulating cell cycle...
2.
Buzby J, Williams S, Schaffer L, Head S, Nugent D
Cancer Genet
. 2017 Mar;
211:9-17.
PMID: 28279309
Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder where an oncogenic TP53 germline mutation is passed from parent to child. Tumor protein p53 is a key tumor suppressor regulating cell...
3.
Buzby J, Williams S, Imfeld K, Kunicki T, Nugent D
Inflamm Res
. 2014 Jan;
63(4):299-308.
PMID: 24385191
Objective And Design: Variable tissue factor (TF) expression by human microvascular endothelial cells (HMVEC) may be regulated by two promoter haplotypes, distinguished by an 18-basepair deletion (D) or insertion (I)...
4.
Kunicki T, Williams S, Nugent D
Curr Opin Hematol
. 2012 Aug;
19(5):371-9.
PMID: 22872156
Purpose Of Review: This review summarizes our current knowledge of common gene variants (polymorphisms) that have small individual effects on platelet function in humans, but can cumulatively lead to hyperreactive...
5.
Kunicki T, Williams S, Diaz D, Farndale R, Nugent D
Haematologica
. 2011 Dec;
97(5):692-5.
PMID: 22133774
A single nucleotide polymorphism in the integrin α2 gene ITGA2 (rs1801106; G1600A) creates the non-conservative amino acid substitution E534K, the basis of the human platelet alloantigen system HPA-5. Yet HPA-5...
6.
Kunicki T, Williams S, Nugent D, Yeager M
Arterioscler Thromb Vasc Biol
. 2011 Oct;
32(1):147-52.
PMID: 22015659
Objective: The interindividual variation in platelet α(2)β(1) exceeds a 2-fold variance in platelet α(IIb)β(3) level. Our objective was to parse the contribution of mean platelet volume (MPV) and integrin gene...
7.
Cheli Y, Williams S, Ballotti R, Nugent D, Kunicki T
PLoS One
. 2010 Jan;
5(1):e8743.
PMID: 20090957
Background: We have identified a cytosine-adenosine (CA) repeat length polymorphism in the 5'-regulatory region of the human integrin alpha2 gene ITGA2 that begins at -605. Our objective was to establish...
8.
Trifiro E, Williams S, Cheli Y, Furihata K, Pulcinelli F, Nugent D, et al.
Blood
. 2009 May;
114(9):1893-9.
PMID: 19465689
The 2 most common haplotypes of human GP6, GP6a and GP6b, generate the allelic isoforms glycoprotein VI (GPVI)a and GPVIb that differ by 5 amino acids: S219P, K237E, and T249A...
9.
Kunicki T, Williams S, Nugent D, Harrison P, Segal H, Syed A, et al.
Thromb Haemost
. 2009 Jan;
101(1):123-33.
PMID: 19132198
We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function...
10.
Chang M, Nakagawa P, Williams S, Schwartz M, Imfeld K, Buzby J, et al.
Blood
. 2003 Apr;
102(3):887-95.
PMID: 12676790
To determine if megakaryocytes are targeted by immune thrombocytopenic purpura (ITP) autoantibodies, as are platelets, we have studied the effects of ITP plasma on in vitro megakaryocytopoiesis. Umbilical cord blood...