Shinji Hirotsune
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Explore the profile of Shinji Hirotsune including associated specialties, affiliations and a list of published articles.
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55
Citations
1942
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Recent Articles
1.
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, et al.
Elife
. 2024 Mar;
12.
PMID: 38529532
Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in...
2.
Jin M, Wang S, Gao X, Zou Z, Hirotsune S, Sun L
Neural Regen Res
. 2023 Oct;
19(4):855-862.
PMID: 37843221
α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons, respectively. Previous works have revealed that intracellular deposition of α-synuclein...
3.
Jin M, Matsumoto S, Ayaki T, Yamakado H, Taguchi T, Togawa N, et al.
Nat Commun
. 2022 Nov;
13(1):6880.
PMID: 36371400
Parkinson's disease is a progressive neurodegenerative disorder characterized by the preferential loss of tyrosine hydroxylase (TH)-expressing dopaminergic neurons in the substantia nigra. Although the abnormal accumulation and aggregation of α-synuclein...
4.
Wang S, Fu Y, Miyata T, Matsumoto S, Shinoda T, Itoh K, et al.
J Neurosci
. 2022 Jul;
42(37):7031-7046.
PMID: 35906071
Alpha-synuclein (αSyn) and tau are abundant multifunctional neuronal proteins, and their intracellular deposits have been linked to many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Despite the disease relevance,...
5.
Penisson M, Jin M, Wang S, Hirotsune S, Francis F, Belvindrah R
Hum Mol Genet
. 2021 Oct;
31(6):942-957.
PMID: 34635911
Human cerebral cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia (bRGs or oRGs)....
6.
Hirotsune S, Kiyonari H, Jin M, Kumamoto K, Yoshida K, Shinohara M, et al.
Sci Rep
. 2020 Feb;
10(1):2518.
PMID: 32054870
The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target...
7.
Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, et al.
Sci Rep
. 2018 May;
8(1):8019.
PMID: 29769584
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
8.
Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, et al.
Sci Rep
. 2017 Nov;
7(1):16386.
PMID: 29180624
Although α-synuclein (αSyn) has been linked to Parkinson's disease (PD), the mechanisms underlying the causative role in PD remain unclear. We previously proposed a model for a transportable microtubule (tMT),...
9.
Kumamoto K, Iguchi T, Ishida R, Uemura T, Sato M, Hirotsune S
Biol Open
. 2017 Jun;
6(7):1041-1055.
PMID: 28630356
The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits...
10.
Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, et al.
Sci Rep
. 2017 Jan;
7:39902.
PMID: 28079116
Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both microcephaly and lissencephaly. Although p80 plays critical roles during brain development, the underlying...