Shin-Ichi Sekizawa
Overview
Explore the profile of Shin-Ichi Sekizawa including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
194
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0
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Recent Articles
1.
Chikamoto A, Tochinai R, Sekizawa S, Kuwahara M
Eur J Neurosci
. 2023 Nov;
58(11):4282-4297.
PMID: 37933572
Duchenne muscular dystrophy (DMD) is a severe progressive neuromuscular disorder that causes cardiac and respiratory failure. Patients with DMD have tachycardia and autonomic nervous dysfunction at a young age, which...
2.
Tochinai R, Kimura K, Saika T, Fujii W, Morita H, Nakanishi K, et al.
Exp Anim
. 2023 Nov;
73(2):145-153.
PMID: 37914289
Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy caused by dystrophin mutations. Inevitable progressive cardiomyopathy is a current leading cause of premature death although respiratory management has improved the...
3.
Nagashima Y, Tochinai R, Sekizawa S, Kato D, Nakagawa T, Tsuru Y, et al.
J Toxicol Pathol
. 2023 Aug;
36(3):151-158.
PMID: 37577366
Combretastatin A4 disodium phosphate (CA4DP) is a prodrug of combretastatin A4 (CA4), a microtubule-disassembling agent that exhibits antitumor effects by inhibiting tumor cell proliferation and inducing morphological changes and apoptosis...
4.
Tochinai R, Nagashima Y, Sekizawa S, Kuwahara M
J Appl Toxicol
. 2023 Jul;
44(1):96-106.
PMID: 37496236
Microtubule polymerization inhibitors (MPIs) have long been used as anticancer agents because they inhibit mitosis. Microtubules are thought to play an important role in the migration of tumor cells and...
5.
Seki N, Tochinai R, Sekizawa S, Marquez M, Fukuda K, Ohmura H, et al.
J Equine Sci
. 2023 Jul;
34(2):55-59.
PMID: 37405067
The Criollo is an Argentine horse breed with a calm temperament. Although its temperament is considered to be related to its neurophysiological characteristics, the details of this are unknown. Therefore,...
6.
Orihara H, Ma M, Nagashima Y, Tochinai R, Sekizawa S, Kato D, et al.
Biomed Pharmacother
. 2023 Feb;
160:114353.
PMID: 36736274
Combretastatin A4 (CA4) inhibits microtubule polymerization, and clinical trials of the prodrug, CA4 disodium phosphate (CA4DP), as an anti-cancer agent have been conducted. However, CA4DP has not been marketed to...
7.
Vitor 2nd R, Tochinai R, Sekizawa S, Kuwahara M
Life (Basel)
. 2022 Nov;
12(11).
PMID: 36430992
Stroke is consistently one of the top ten causes of morbidity and mortality globally, whose outcomes are quite variable, necessitating case-specific management. Prophylactic diets before the onset of stroke have...
8.
Hsu J, Sekizawa S, Tochinai R, Kuwahara M
PLoS One
. 2021 May;
16(5):e0251495.
PMID: 34010316
Baroreflex dysfunction is partly implicated in hypertension and one responsible region is the dorsal medulla oblongata including the nucleus tractus solitarius (NTS). NTS neurons receive and project glutamatergic inputs to...
9.
Kaneko K, Chikamoto A, Hsu J, Tochinai R, Sekizawa S, Yamamoto M, et al.
Exp Anim
. 2019 Nov;
69(2):161-167.
PMID: 31735765
Environmental enrichment (EE) can reduce anxiety and stress in experimental animals, while little is known about the influence on autonomic nervous activity especially in disease animal models. Diabetes mellitus (DM)...
10.
Chikamoto A, Sekizawa S, Tochinai R, Kuwahara M
Exp Anim
. 2019 Jun;
68(4):511-517.
PMID: 31168043
The senescence-accelerated mouse (SAM) strain has been established as an inbred strain with an accelerated aging phenotype. SAM prone-8 (SAMP8), one of the SAM strain, exhibits learning disability, immune deficiency,...